Results 61 to 70 of about 47,275 (224)

Differences in Risk Factors for Severe Preeclampsia and HELLP Syndrome in Singleton Versus Twin Pregnancies: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine whether the associations between pre‐pregnancy risk factors and severe preeclampsia/eclampsia (SPE) and/or HELLP syndrome differ between singleton and twin pregnancies. Design A population‐based retrospective cohort study. Setting British Columbia (BC), Canada.
Mackenzie Campbell, Johanna Koegl, Jeffrey N. Bone, Sofia Nicolls, Janet Lyons, Chantal Mayer, Kenneth I Lim, Julie Van Schalkwyk, K. S. Joseph, Sarka Lisonkova, the ORQA group, A. Christoffersen‐Deb, S. Derikvand, S. John, L. Richter, M. Rougerie, Y. Sabr, M. Vidler   +17 more
wiley   +1 more source

Gut‐Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundGut microbiota is emerging as a novel risk factor for atherothrombosis, but the predictive role of gut‐derived lipopolysaccharide (LPS) is unknown.
Daniele Pastori, Roberto Carnevale, Cristina Nocella, Marta Novo, Maria Santulli, Vittoria Cammisotto, Danilo Menichelli, Pasquale Pignatelli, Francesco Violi   +8 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Additive effect of cysteinyl leukotriene or thromboxane modifiers to inhaled corticosteroids in asthmatic patients

Allergology International, 2004
Bronchial asthma is a chronic inflammatory disease of the conducting airways. Current asthma treatment guidelines recommend inhaled corticosteroids (ICS) as the first-line maintenance therapy for mild to severe persistent asthma, because ICS are the most
Shigeharu Myou, Masaki Fujimura, Alan R Leff   +2 more
doaj   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Phospholipid derived mediators and glomerulonephritis

Mediators of Inflammation, 1993
The contributions made by the various eicosanoids, PAF, the HETES and the lipoxins to the pathophysiology of glomerulonephritis is reviewed. A case can be made for clinical trials of PAF, leukotriene and thromboxane antagonists.
E. N. Wardle
doaj   +1 more source

Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundPersistent thromboxane (TX) generation while receiving aspirin therapy is associated with an increased risk of cardiovascular events. The Reduction in Graft Occlusion Rates (RIGOR) study found that aspirin‐insensitive TXA2 generation, indicated
Nikolaos Kakouros, Susanna M. Nazarian, Patrizia B. Stadler, Thomas S. Kickler, Jeffrey J. Rade   +4 more
doaj   +1 more source

Dietary melatonin and its benefits on cardiovascular disease

British Journal of Pharmacology, EarlyView.
Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane, Carmelita Abrahams, Sandrine Lecour   +2 more
wiley   +1 more source

Complement Activation-Related Pathophysiological Changes in Anesthetized Rats: Activator-Dependent Variations of Symptoms and Mediators of Pseudoallergy

Molecules, 2019
Complement (C) activation can underlie the infusion reactions to liposomes and other nanoparticle-based medicines, a hypersensitivity syndrome that can be partially reproduced in animal models.
László Dézsi, Tamás Mészáros, Erik Őrfi, Tamás G. Fülöp, Mark Hennies, László Rosivall, Péter Hamar, János Szebeni, Gábor Szénási   +8 more
doaj   +1 more source

Digoxin and Platelet Activation in Patients With Atrial Fibrillation: In Vivo and In Vitro Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Digoxin use was shown to be associated with an increased risk of cardiovascular events in atrial fibrillation (AF). We hypothesized that digoxin may affect cardiovascular risk by increasing platelet activation.
Daniele Pastori, Roberto Carnevale, Cristina Nocella, Simona Bartimoccia, Marta Novo, Vittoria Cammisotto, Silvia Piconese, Maria Santulli, Fortunata Vasaturo, Francesco Violi, Pasquale Pignatelli   +10 more
doaj   +1 more source