Results 71 to 80 of about 47,275 (224)
ALOX15 links lipid metabolism to receptor trafficking in platelet activation
The FEBS Journal, EarlyView.This schematic summarizes known and newly identified mechanisms of thrombin‐mediated platelet activation. In addition to classical thrombin‐induced PAR4 signaling pathways, thrombin activates an ALOX15–HETE–PKCθ–NMT1 signaling cascade that promotes protein myristoylation, facilitates receptor trafficking, and enhances PAR4 surface expression on ...
Yosef Eshetie Amare +2 more
wiley +1 more source
Thromboxane receptor-mediated bronchial and hemodynamic responses in ovine endotoxemia
, 1988 The role of thromboxane A2 in sheep endotoxemia, an animal model of the adult respiratory distress syndrome, was investigated by a combined biochemical and pharmacological approach. Endogenous thromboxane biosynthesis was assessed by gas chromatographic-
P. G. Kuhl +4 more
core +1 more source
Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community
Haemophilia, EarlyView.ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein +6 more
wiley +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic +3 more
wiley +1 more source
Investigation of thromboxane A2 synthase knockout mice
, 2007 Thromboxane A2合成酶(TXA2 synthase)所生產的TXA2具有引發血小板凝集、血管收縮及調節腎臟等功能，且在包含心肌梗塞、中風、氣喘及許多的腎臟疾病發生的過程中均扮演重要的角色。除了參與眾所周知的凝血與血栓形成外，TXA2被認為可能參與血小板生成及淋巴球的分化。為了進一步了解其生理功能，本論文以基因轉殖的方式製作TXA2合成酶基因剔除(TXAS-/-)小鼠模式。分析結果發現TXAS-/-小鼠具有正常的骨髓巨核細胞，其胸腺及脾臟的淋巴球數量也正常。但其出血時間異常且以花生四烯酸 ...
Yu, I-Shing, 游益興
core
The biochemical pharmacology of thromboxane synthase inhibition in man.
, 1985 Selective inhibitors of thromboxane synthase have two theoretical advantages over inhibitors of the cyclooxygenase enzyme as potential antithrombotic compounds.
A K Pedersen, I A Reilly, G A FitzGerald
core +1 more source
Possible mechanism of action of Mentha Arvensis in cardiovascular diseases
International Journal of Endorsing Health Science Research, 2014 Mentha arvensis (MA) is traditionally used in hypertension and in patients with ischemic heart disease. The scientific rationale for its use is not known.
Saima Gul, Humaira Gul, Rukhsana Nawaz
doaj +1 more source
Testing for Non‐Severe Heritable Platelet Function Disorders
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley +3 more
wiley +1 more source
, 1985 Despite numerous suggestions in the literature that thromboxane A2 is involved in a variety of occlusive vascular diseases, no definitive evidence is available.
M C Carter +9 more
core +1 more source
AntioxidantsAlterations in the gastric mucosal barrier, one of whose fundamental components is phosphatidylcholine (PC), may play an important role in the pathophysiology of erosive gastritis secondary to sepsis.
Sergio D. Paredes +5 more
doaj +1 more source