Prostacyclin: An inflammatory paradox. [PDF]
Frontiers in Pharmacology, 2011 Prostacyclin (PGI2) is a member of the prostaglandin family of bioactive lipids. Its best-characterized role is in the cardiovascular system, where it is released by vascular endothelial cells, serving as a potent vasodilator and inhibitor of platelet ...
Jeremiah eStitham +3 more
doaj +4 more sources
Development of Methodology for the Measurement of Prostacyclin and Thromboxane Production: Possible Relevance of Prostacyclin/Thromboxane Balance in Clinical Conditions [PDF]
, 1986 This thesis describes the historical development of our knowledge of prostaglandins and thromboxane and the synthesis, metabolism and actions of prostacyclin and thromboxane.
McLaren, Margaret
core +6 more sources
Lung-Cardiovascular Interactions and Derangements in ARDS. [PDF]
Compr PhysiolThis review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Sanchez PA +4 more
europepmc +2 more sources
Portopulmonary hypertension practice patterns after liver transplantation
Liver Transplantation, EarlyView., 2022 Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose +3 more
wiley +1 more source
Searching the ideal inhaled vasodilator: From nitric oxide to prostacyclin [PDF]
, 2002 Today, the technique to directly administer vasodilators via the airway to treat pulmonary hypertension and to improve pulmonary gas exchange is widely accepted among clinicians.
Kleen, Martin +5 more
core +1 more source
Prostanoids and Resolution of Inflammation – Beyond the Lipid-Mediator Class Switch
Frontiers in Immunology, 2021 Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein, early pro-inflammatory phases are characterized and regulated by prostanoids and leukotrienes, whereas specialized pro-resolving mediators (SPM), including lipoxins,
Tobias Schmid +4 more
doaj +1 more source
Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility [PDF]
, 2005 Inhaled prostacyclin (PGI(2)) aerosol induces selective pulmonary vasodilation. Further, it improves right ventricular ( RV) function, which may largely rely on pulmonary vasodilation, but also on enhanced myocardial contractility.
Thein, E. +12 more
core +1 more source
The Egyptian Heart Journal, 2021 Background COVID-19 associated acute respiratory distress syndrome (CARDS) is a severe form of SARS CoV-2 infection and affects about 15–30% of hospitalized patients with a high mortality rate.
Eka Prasetya Budi Mulia, Kevin Luke
doaj +1 more source
Pulmonary Circulation, 2020 Prostacyclin pathway agents are a critical treatment for patients with pulmonary arterial hypertension. Seven prostacyclin pathway agents are available, including agents administered by parenteral infusion, by inhalation, and orally.
Therese Sargent +2 more
doaj +1 more source
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression [PDF]
, 2013 PMCID: PMC3711559This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Anna Nicolaou (261799) +63 more
core +2 more sources