Results 171 to 180 of about 12,109,427 (256)

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Balancing dose preservation and treatment efficiency in motion-managed magnetic resonance image-guided radiotherapy of pancreatic cancer. [PDF]

Phys Imaging Radiat Oncol
Bernchou U, Brink C, Bahij R, Bertelsen AS, Schytte T, Mahmood F.   +5 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Adaptive Target Volume and Dosimetry in Image-Guided Radiotherapy for Cervical Cancer. [PDF]

J Clin Med
Manea E, Anghel B, Stanescu AD, Rata AM, Gafton B, Scripcariu V.   +5 more
europepmc   +1 more source

Image-guided radiotherapy in an orthotopic mouse model of rectal cancer. [PDF]

STAR Protoc, 2022
Nicolas AM, Pesic M, Rödel F, Fokas E, Greten FR.   +4 more
europepmc   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Investigation of the impact of image-guided radiotherapy selection on image registration results and non-coding RNAs for cervical cancer patients. [PDF]

Noncoding RNA Res
Cheng C, Yang Y, Qu Y.
europepmc   +1 more source

Endoscopically placed fiducial markers for image-guided radiotherapy in preoperative gastric cancer: Technical feasibility and potential benefit. [PDF]

Endosc Int Open, 2023
Bleeker M, van der Horst A, Bel A, Sonke JJ, van Hooft JE, Pouw RE, Hulshof MCCM.   +6 more
europepmc   +1 more source

Carrier‐Free Stimulus‐Responsive Theranostic Nanoprodrug Enabling GSH‐Consumption‐Promoted Chemo‐Photodynamic Cancer Therapy

Advanced Science, EarlyView.
Leveraging the critical role of glutathione (GSH) in mediating drug resistance and scavenging reactive oxygen species (ROS) in cancer cells, a carrier‐free GSH‐consuming theranostic nanoprodrug, consisting of a BODIPY photosensitizer and the chemotherapeutic drug paclitaxel linked through a GSH‐consuming drug linker, is developed to deeply explore the ...
Hansheng Huang, Binglin Sui
wiley   +1 more source

Performance evaluation of a second-generation O-ring-shaped image-guided radiotherapy system with a gimbal-mounted linear accelerator and real-time tracking capabilities. [PDF]

J Appl Clin Med Phys
Kawata K, Kishigami Y, Hirashima H, Sawada Y, Urago M, Fujimoto T, Fukuda T, Mizowaki T, Nakamura M.   +8 more
europepmc   +1 more source