Results 41 to 50 of about 70,141 (253)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Current advances in radiotherapy for soft tissue sarcomas

Nowotwory, 2020
Radiotherapy (RT) is a part of the routine treatment of locally advanced or high-grade soft-tissue sarcomas (STS). However, RT has changed significantly over the last 20 years. Modern RT techniques have extended its potential application in STS treatment.
Mateusz J. Spałek, Aneta M. Borkowska
doaj   +1 more source

Leaf-individual calibration for a double stack multileaf collimator in photon radiotherapy

Physics and Imaging in Radiation Oncology, 2023
Background and Purpose: In online adaptive stereotactic body radiotherapy treatments, linear accelerator delivery accuracy is essential. Recently introduced double stack multileaf collimators (MLCs) have new facets in their calibration.
Carolin Rippke, C. Katharina Renkamp, Charbel Attieh, Fabian Schlüter, Carolin Buchele, Jürgen Debus, Markus Alber, Sebastian Klüter   +7 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

A comparison of treatment outcome between fiducial-based and bone-based image guided radiotherapy in prostate cancer patients

Radiation Oncology, 2018
Background and purpose To compare the clinical outcome in prostate cancer patients treated with radiotherapy using two forms of image guidance: bone-based (BB) or fiducial-based (FB).
Aleksandra Napieralska, Wojciech Majewski, Roland Kulik, Grzegorz Głowacki, Leszek Miszczyk   +4 more
doaj   +1 more source

MRI-LINAC: A transformative technology in radiation oncology

Frontiers in Oncology, 2023
Advances in radiotherapy technologies have enabled more precise target guidance, improved treatment verification, and greater control and versatility in radiation delivery.
John Ng, Fabiana Gregucci, Fabiana Gregucci, Ryan T. Pennell, Himanshu Nagar, Encouse B. Golden, Jonathan P. S. Knisely, Nicholas J. Sanfilippo, Silvia C. Formenti   +8 more
doaj   +1 more source

Accurate,robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy [PDF]

, 2019
In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by means of a robust and accurate treatment planning system.
Baeza, José Antonio, Balcerzyk, Marcin, García-Gómez, Francisco Javier, Jiménez Ortega, Elisa Eugenia, Leal Plaza, Antonio, Parrado-Gallego, Ángel, Pereira Barbeiro, Ana Rita, Ureba Sánchez, Ana María, Wals-Zurita, Amadeo   +8 more
core   +2 more sources

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

Rationale and development of image-guided intensity-modulated radiotherapy post-prostatectomy: the present standard of care?

Cancer Management and Research, 2015
Julia R Murray,1,2 Helen A McNair,2 David P Dearnaley1,2 1Academic Urology Unit, Institute of Cancer Research, London, 2Department of Radiotherapy, The Royal Marsden NHS Foundation Trust, Sutton, UK Abstract: The indications for post-prostatectomy ...
Murray JR, McNair HA, Dearnaley DP
doaj  

Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation

Frontiers in Immunology, 2022
IntroductionIn situ tumor ablation releases a unique repertoire of antigens from a heterogeneous population of tumor cells. High-intensity focused ultrasound (HIFU) is a completely noninvasive ablation therapy that can be used to ablate tumors either by ...
Renske J. E. van den Bijgaart, Vera E. Mekers, Fabian Schuurmans, Tonke K. Raaijmakers, Melissa Wassink, Andor Veltien, Erik Dumont, Arend Heerschap, Jurgen J. Fütterer, Jurgen J. Fütterer, Gosse J. Adema   +10 more
doaj   +1 more source