Results 171 to 180 of about 12,109,428 (256)

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Radiation therapist (RTT) perspectives on developing image-guided radiotherapy (IGRT) protocols for reirradiation. [PDF]

Tech Innov Patient Support Radiat Oncol
Duffton A, Devlin L, Williamson A, Grose D, Tolmie E, MacLaren L, McFadden S, Muirhead R.   +7 more
europepmc   +1 more source

Risk Factors for Nodal Failure in Patients with FIGO IIIC Cervical Cancer Receiving Definitive Image-Guided Radiotherapy. [PDF]

Curr Oncol, 2023
Liu X, Hou X, Hu K, Zhang F, Wang W, Ren K.   +5 more
europepmc   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Online adaptive radiotherapy in pelvic and thoracic cancers - comparing toxicities, clinical outcomes and technical parameters between conventional image-guided radiotherapy and online adaptive radiotherapy - the study protocol for the prospective, registry-based cohort study (PRoART). [PDF]

BMC Med Imaging
Fischer LA, Fischer J, Scheele NC, Droege LH, Leu M, Guhlich M, Oelmann-Avendano JT, Hille A, Bendrich S, Donath S, Knaus O, Ziegler DA, Zwerenz CM, Anczykowski MZ, Ammon HE, Luise Bergau PF, Pagel CF, Schirmer MA, Wenzel AR, Frohn J, Bensberg J, Strauß A, Asendorf T, Schmitt D, Rieken S, El Shafie RA.   +25 more
europepmc   +1 more source

Advances in Image-Guided Radiotherapy in the Treatment of Oral Cavity Cancer. [PDF]

Cancers (Basel), 2022
Nien HH, Wang LY, Liao LJ, Lin PY, Wu CY, Shueng PW, Chung CS, Lo WC, Lin SC, Hsieh CH.   +9 more
europepmc   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

An open-source motion platform that replicates time synchronised internal and external patient motion for real-time image-guided radiotherapy. [PDF]

Phys Eng Sci Med
Kaczynska A, Kuban C, Zahr A, Nixon W, Keall P, Jin F, Yan A, Mason D, Stewart M, Johnson J, Hindmarsh J, Sengupta C.   +11 more
europepmc   +1 more source

Electron stream effect in 0.35 Tesla magnetic resonance image guided radiotherapy for breast cancer. [PDF]

Front Oncol, 2023
Lee HH, Wang CY, Chen ST, Lu TY, Chiang CH, Huang MY, Huang CJ.   +6 more
europepmc   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source