Results 91 to 100 of about 309,496 (294)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Effect of Quantitative Nuclear Image Features on Recurrence of Ductal Carcinoma In Situ (DCIS) of the Breast

Cancer Informatics, 2008
Background: Nuclear grade has been associated with breast DCIS recurrence and progression to invasive carcinoma; however, our previous study of a cohort of patients with breast DCIS did not find such an association with outcome. Fifty percent of patients
Judith-Anne W. Chapman, Yuejiao Fu, Yan Yuan, William A. Christens-Barry, Jin Qian, H. Lavina Lickley, Naomi A. Miller, David E. Axelrod   +7 more
doaj  

Malignancy-Associated Changes in Breast Tissue Detected by Image Cytometry

Analytical Cellular Pathology, 2000
In several tissues, nuclear differences have been described in normal‐appearing cells from patients with invasive carcinomas compared to cases without invasive carcinoma, a phenomenon known as malignancy‐associated changes (MACs).
Ellen C. M. Mommers, Neal Poulin, Chris J. L. M. Meijer, Jan P. A. Baak, Paul J. van Diest   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Tissue Cytometry Assay with Nuclear Segmentation for Quantifying NETotic Cells in Neutrophils Stimulated by Spermatozoa in Veterinary Species

Animals
Upon activation, neutrophils perform three distinct functions: phagocytosis, degranulation of antimicrobial substances into the extracellular medium, and release of neutrophil extracellular traps.
Rodrigo Rivera-Concha, Marion León, Nikol Ponce-Rojas, Aurora Prado-Sanhueza, Pamela Uribe, Anja Taubert, Carlos Hermosilla, Raúl Sánchez, Fabiola Zambrano   +8 more
doaj   +1 more source

Prognostic Impact of DNA-Image-Cytometry in Neuroendocrine (Carcinoid) Tumours

Cellular Oncology, 2004
Establishing prognosis proves particularly difficult with neuroendocrine tumours (NETs) as a benign looking histology can be associated with a malignant behaviour.
H. Raatz, A. Böcking, S. Hauptmann
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole slide imaging with accurate single-cell segmentation [PDF]

, 2023
Eun Na Kim, Phyllis Zixuan Chen, Dario Bressan, Monika Tripathi, Ahmad Miremadi, Massimiliano di Pietro, Lisa M. Coussens, Gregory J. Hannon, Rebecca C. Fitzgerald, Lizhe Zhuang, Young Hwan Chang   +10 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

DeepIFC : Virtual fluorescent labeling of blood cells in imaging flow cytometry data with deep learning [PDF]

, 2023
Veera A. Timonen, Erja Kerkelä, Ulla Impola, Leena Penna, Jukka Partanen, Outi Kilpivaara, Mikko Arvas, Esa Pitkänen   +7 more
openalex   +1 more source