Results 51 to 60 of about 242,521 (294)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Comparison of Flow Cytometry and Image-Based Screening for Cell Cycle Analysis
, 2016 Quantitative cell state measurements can provide a wealth of information about mechanism of action of chemical compounds and gene functionality. Here we present a comparison of cell cycle disruption measurements from commonly used flow cytometry ...
Wählby, Carolina +11 more
core +1 more source
, 2023 IntroductionMonitoring of innate myeloid cells (IMC) is broadly applied in basic and translational research, as well as in diagnostic patient care.
Kassem, Sara +25 more
core +1 more source
Image3C, a multimodal image-based and label-independent integrative method for single-cell analysis
eLife, 2021 Image-based cell classification has become a common tool to identify phenotypic changes in cell populations. However, this methodology is limited to organisms possessing well-characterized species-specific reagents (e.g., antibodies) that allow cell ...
Alice Accorsi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping
, 2019 Cellular biophysical properties are the effective label-free phenotypes indicative of differences in cell types, states, and functions. However, current biophysical phenotyping methods largely lack the throughput and specificity required in the majority ...
Chan, GCF +6 more
core +1 more source
Artificial intelligence in imaging flow cytometry
Frontiers in Bioinformatics, 2023 Imaging flow cytometry (IFC) is a powerful screening technique that combines the advantages of flow cytometry and optical microscopy (Basiji et al., 2007; Rees et al., 2022). By capturing microscopy images of the specimens as they move along a liquid stream, IFC provides high-throughput collection of morphological and spatial information from thousands
Pozzi P. +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
TICAL - a web-tool for multivariate image clustering and data topology preserving visualization [PDF]
, 2011 Langenkämper D, Kölling J, Abouna S, Khan M, Niehaus K, Nattkemper TW. TICAL - a web-tool for multivariate image clustering and data topology preserving visualization.
Nattkemper, Tim Wilhelm ; https://orcid.org/ +5 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source