Results 61 to 70 of about 242,521 (294)
Multiparametric assessment of Cd2+ cytotoxicity using MTT-based microfluidic image cytometry
, 2012 A modified MTT protocol-based microfluidic image cytometry (mu FIC) was performed to assess Cd2+ induced cytotoxicity. The expanded capabilities of mu FIC, such as in situ measurement, high-throughput, and multiparametric analysis of adherent cells under
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core +1 more source
, 2023 IntroductionMonitoring of innate myeloid cells (IMC) is broadly applied in basic and translational research, as well as in diagnostic patient care.
Kassem, Sara +25 more
core +1 more source
SEM–Raman image cytometry of cells
The Analyst, 2018 Hybrid SEM–Raman microscopy to distinguish individual human cells.
A. Enciso-Martinez +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2016 a) DNA content histograms created with PopulationProfiler. The blue and red lines show data before and after smoothing, respectively. The numbers under the x-axis present the percentage contribution of each cell cycle sub-population. b) The corresponding
Jordi Carreras Puigvert (3177423) +3 more
core +1 more source
Nature Communications, 2020 Strategies to increase T cell infiltration within the tumor microenvironment could improve response to immune checkpoint blockade. Here the authors show that a combinatorial regimen based on Flt3L, radiotherapy, and TLR3/CD40 stimulation promotes ...
Takaaki Oba +7 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
High-throughput analysis of TUNEL-stained sperm using image cytometry
, 2020 Sperm DNA integrity is an essential factor for successful fertilization and proper pregnancy progression. The terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) assay is commonly used for the estimation of the DNA fragmentation index ...
Arifulin E.A. +3 more
core +2 more sources
Blood Advances, 2017 : Multiple therapeutic options exist for multiple myeloma (MM), including autologous hematopoietic stem cell transplantation (AHSCT). Measurement of minimal residual disease (MRD) and immune reconstitution is rapidly becoming an integral part of the care
Christine M. Ho +13 more
doaj +1 more source