Results 151 to 160 of about 813,438 (205)

Establishment and biological characterization of radioresistant colorectal cancer cell lines

FEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu, Qing Dai, Jing Leng, Lin Fang, Jing‐Jing Ma, Rui Chen, Che Chen, Peng‐Fei Ran, Wen‐Wen Zhou, Chang Liu, Huang‐Fei Yu   +10 more
wiley   +1 more source

Radiomics workflow definition & challenges - German priority program 2177 consensus statement on clinically applied radiomics

Insights into Imaging
Objectives Achieving a consensus on a definition for different aspects of radiomics workflows to support their translation into clinical usage. Furthermore, to assess the perspective of experts on important challenges for a successful clinical workflow ...
Ralf Floca, Jonas Bohn, Christian Haux, Benedikt Wiestler, Frank G. Zöllner, Annika Reinke, Jakob Weiß, Marco Nolden, Steffen Albert, Thorsten Persigehl, Tobias Norajitra, Bettina Baeßler, Marc Dewey, Rickmer Braren, Martin Büchert, Eva Maria Fallenberg, Norbert Galldiks, Annika Gerken, Michael Götz, Horst K. Hahn, Johannes Haubold, Tobias Haueise, Nils Große Hokamp, Michael Ingrisch, Andra-Iza Iuga, Marco Janoschke, Matthias Jung, Lena Sophie Kiefer, Philipp Lohmann, Jürgen Machann, Jan Hendrik Moltz, Johanna Nattenmüller, Tobias Nonnenmacher, Benedict Oerther, Ahmed E. Othman, Felix Peisen, Fritz Schick, Lale Umutlu, Barbara D. Wichtmann, Wenzhao Zhao, Svenja Caspers, Heinz-Peter Schlemmer, Christopher L. Schlett, Klaus Maier-Hein, Fabian Bamberg   +44 more
doaj   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Computerized brain tumor segmentation in magnetic resonance imaging

Einstein (São Paulo), 2012
OBJECTIVE: To propose an automatic brain tumor segmentation system. METHODS: The system used texture characteristics as its main source of information for segmentation. RESULTS: The mean correct match was 94% of correspondence between the segmented areas
Maryana de Carvalho Alegro, Edson Amaro Junior, Rosei de Deus Lopes   +2 more
doaj  

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

A new adaptive diffusive function for magnetic resonance imaging denoising based on pixel similarity

Journal of Medical Signals and Sensors, 2015
Although there are many methods for image denoising, but partial differential equation (PDE) based denoising attracted much attention in the field of medical image processing such as magnetic resonance imaging (MRI).
Mostafa Heydari, Mohammad Reza Karami
doaj  

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

A Review of Computer-Aided Detection of Pulmonary Embolism in CT Angiograms

مجله انفورماتیک سلامت و زیست پزشکی, 2016
Introduction: pulmonary computed tomography angiography (CTA) is widely used in the detection of pulmonary embolism. Using these thin slices for studying clinical function of lung is necessary, but it is time-consuming for radiologists.
Mojtaba Masoudi, Hamidreza Pourreza, Mahdi Saadatmand, Fateme Shafiei Zargar, Mahnaz Amini, Masoud Pezeshki Rad   +5 more
doaj