Results 111 to 120 of about 215,997 (243)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Before Imagination Embodied Thought from Montaigne to Rousseau
A study of the practice of vivid, self-directed imagination in the optimistic spirit of the early-modern French writers.Intro -- Contents -- Preface -- Acknowledgments -- Introduction -- 1 The Return of Stoic Imagination -- 2 Self-Cultivation and ...
Lyons, John D.
core
A return to the reader and their imagination: the forming of a referential world in order to establish meaning in a text [PDF]
, 2015 The goal of this text is to reassert the importance of the imagination and the reader in the process of reading. It is my experience that the reader and text interaction has come to be dismissed as being too prone to individuation.
Smith, Michael D. +1 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
LateralThere is a rise in events connecting people to food, the sources of food, and the materiality of food––including all its affective and sensorial qualities.
Paulina Lanz, Sulafa Zidani
doaj +1 more source
¿IMAGINED FREEDOM OR ANARCHISTIC IMAGINATION?
, 2011 In 1936, Sartre published a text entitled "Imagination", which will be the prelude to another one published in 1940 and called "Imaginary". A few years later, in 1947 published, in a first volume to be called "Situations I", miscellaneous items, one of which is entitled "Cartesian Freedom".This article is in principle based on these three texts, from ...
openaire +3 more sources
(Creatures of imagination : on dreams and the radical imagination)
, 2015 This paper is driven by the conviction that the imagination names a field that far exceeds anything able to be spoken of as a power, a faculty, or something at our disposal.
Schmidt, Dennis J. (R18285)
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source