Results 131 to 140 of about 179,692 (309)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Before Imagination Embodied Thought from Montaigne to Rousseau
A study of the practice of vivid, self-directed imagination in the optimistic spirit of the early-modern French writers.Intro -- Contents -- Preface -- Acknowledgments -- Introduction -- 1 The Return of Stoic Imagination -- 2 Self-Cultivation and ...
Lyons, John D.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Travel and imagination : an invitation
, 2014 There is always a risk when we venture onto new theoretical terrain that we will forget some of the important things we learnt elsewhere. In our calls for a retheorization of the imagination together with travel, then, we want to be explicit with our ...
Waterton, Emma (R16010) +1 more
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¿IMAGINED FREEDOM OR ANARCHISTIC IMAGINATION?
, 2011 In 1936, Sartre published a text entitled "Imagination", which will be the prelude to another one published in 1940 and called "Imaginary". A few years later, in 1947 published, in a first volume to be called "Situations I", miscellaneous items, one of which is entitled "Cartesian Freedom".This article is in principle based on these three texts, from ...
openaire +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2007 Imagination is a capacity of internal visualization, concept creation and manipulation not directly dependent upon sensation. Imagination is associated with a range of phenomena: mental imagery, fancy, inventiveness, insight, counterfactual reasoning ...
Devitt, S. Kate
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
ludzeller/Sonic-Imagination-Sensor-Firmware: v0.5.3
<h2>What's Changed</h2> <ul> <li>Refactor file structure by @iromur in https://github.com/ludzeller/Sonic-Imagination-Sensor-Firmware/pull/3</li> </ul> <p><strong>Full Changelog</strong>: https ...
Martin Rumori, Ludwig Zeller
core +1 more source