Results 141 to 150 of about 179,692 (309)

The role of imagination in Bergman, Klein and Sartre [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityThis thesis provides an inter-disciplinary study of selected works by Ingmar Bergman.
Williams, Daniel
core  

Creativity and Schizophrenia Spectrum Disorders

open access: yesFrontiers in Psychology, 2014
Scott Barry Kaufman   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Melville's Monumental Imagination

open access: yes
Melville's Monumental Imagination explores the connection between the contested 19th century American monument tradition and one of the nation's most revered authors, Herman Melville (1819-1891).
Maloney, Ian S.
core  

The Son and the other stars: Christology and cosmology in the imagination of C.S. Lewis

open access: yes, 2012
This dissertation treats the theory and practice of C. S. Lewis's theological imagination, focussing upon the imaginative use he made of his professional expertise in medieval and renaissance literature.
Ward, Michael
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

NCRM podcast: Narrative imagination and everyday life

open access: yes, 2013
From the challenge of envisioning our own futures to the storytelling skills of Barack Obama, a new book from the Professor Molly Andrews (NOVELLA node) explores how the links between stories and imagination affect the way we live.
Andrews, Molly
core  

From the first to the third Critique: Non-conceptual content and the fate of the imagination

open access: yes, 2020
The faculty of imagination and its role in the Critique of the Power of Judgement are at the hearth of a very important controversy: Is aesthetic judgement conceptual?
Sakızlı, Selda Salman
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

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