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CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human
Advanced Science, EarlyView.This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan +21 more
wiley +1 more source
Advanced Science, EarlyView.This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir +7 more
wiley +1 more source
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Mass Cytometry, Imaging Mass Cytometry, and Multiplexed Ion Beam Imaging Use in a Clinical Setting
Clinics in Laboratory Medicine, 2021Mass cytometry (MC), imaging mass cytometry (IMC), and multiplexed ion beam imaging (MIBI) represent a new generation of tools to understand increasingly complex systems. Although these technologies differ in their intended applications, with MC being most similar to flow cytometry, and IMC/MIBI being similar to immunohistochemistry, they all share a ...
Raymond D, Devine, Gregory K, Behbehani
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Automated Cell Phenotyping for Imaging Mass Cytometry
2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2022Imaging mass cytometry (IMC) is a new advancement in tissue imaging that is quickly gaining wider usage since its recent launch. It improves upon current tissue imaging methods by allowing for a significantly higher number of proteins to be imaged at once on a single tissue slide. For most analyses of IMC data, determining the phenotype of each cell is
Sindhura, Thirumal +4 more
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Imaging Mass Cytometry in Immuno-Oncology
2023In situ profiling of the tumor-immune microenvironment (TiME) requires the ability to co-localize and detect multiple proteins simultaneously. Imaging mass cytometry (IMC), using the Hyperion™ imaging system is a novel multiplex imaging modality that currently enables detection of up to 50 markers on fixed tissues at subcellular resolution and thus has
Tiziana, Cotechini +2 more
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Signal Amplification for Imaging Mass Cytometry
Bioconjugate Chemistry, 2019An enzyme-catalyzed reporter deposition stain has been developed for Imaging Mass Cytometry (IMC). The reagent consists of an alkaline phosphatase substrate tethered to a tellurophene which serves as reporter group for mass cytometry. Upon phosphate hydrolysis, a quinone methide is released which covalently labels local nucleophiles. This strategy is a
Rahul Rana +3 more
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Ruthenium counterstaining for imaging mass cytometry
The Journal of Pathology, 2018AbstractImaging mass cytometry is a novel imaging modality that enables simultaneous antibody‐based detection of >40 epitopes and molecules in tissue sections at subcellular resolution by the use of isotopically pure metal tags. Essential for any imaging approach in which antigen detection is performed is counterstaining, which reveals the overall ...
Catena, Raúl +2 more
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DNA-Conjugated Gold Nanoparticles as High-Mass Probes in Imaging Mass Cytometry
ACS Applied Bio Materials, 2019We employ imaging mass cytometry (IMC) to investigate in vitro uptake and cellular distribution of DNA-functionalized gold nanoparticles (AuNPs). IMC enables the multiparametric imaging of cell components and allows for the detection of AuNPs in cells with >100 times higher sensitivity than conventional confocal fluorescence imaging, as each ...
Brian Malile +6 more
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