Results 101 to 110 of about 1,882,249 (253)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Materials for phantoms for terahertz pulsed imaging [PDF]

, 2004
Phantoms are commonly used in medical imaging for quality assurance, calibration, research and teaching. They may include test patterns or simulations of organs, but in either case a tissue substitute medium is an important component of the phantom.
Berry, E., Brettle, D.S., Smye, Stephen W., Walker, Gillian Claire, Berry, Elizabeth, Smye, S.E., Walker, G.C., Brettle, David S.   +7 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Realistic 3D printed imaging tumor phantoms for validation of image processing algorithms [PDF]

, 2022
Medical imaging phantoms are widely used for validation and verification of imaging systems and algorithms in surgical guidance and radiation oncology procedures.
Lorenz, Andrea, Kettenbach, Joachim, Patsch, Janina, Figl, Michael, Strassl, Andreas, Kronreif, Gernot, Renner, Andreas, Georg, Dietmar, Birkfellner, Wolfgang, Hatamikia, Sepideh, Gulyas, Ingo, Unger, Alexander, Unger, Ewald, Oberoi, Gunpreet   +13 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Placenta Vasculature 3D Printed Imaging and Teaching Phantoms [PDF]

, 2016
Three-dimensional printing makes it possible to create patient-specific, complex anatomical geometries that can be used for training, teaching and surgical planning.
Hill, E. R., Hill, E, Vercauteren, T.; id_orcid, Desjardins, AE, David, A. L., Daher, B., Vercauteren, T, Wong, R. Y.J., Xia, W, Wong, RYJ, Nikitichev, D, David, AL, Nikitichev, D. I., Xia, W.; id_orcid, Ourselin, S, Desjardins, A. E., Daher, B, Ourselin, S.; id_orcid   +17 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Microwave Radar-Based Differential Breast Cancer Imaging: Imaging in Homogeneous Breast Phantoms and Low Contrast Scenarios

, 2010
This paper presents an improved antenna array for radar-based breast cancer imaging. The improvement was achieved by increasing the number of antennas in the array to 31 elements, as well as by improving the antenna design itself.
Preece, Alan W, Leendertz, Jack, Klemm, Maciej, Benjamin, Ralph, Craddock, Ian J, Gibbins, David R, Alan Preece, David Gibbins, Ralph Benjamin, Ian J Craddock, Jack A Leendertz, Maciej Klemm   +11 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Hybrid organosilicon/polyol phantoms for applications in biophotonics and beyond

, 2020
Recent advances of medical technologies are demanding a new generation of phantoms that may encode the biophysical features needed for their aßeßment. Here, we propose hybrid materials based on emulsions of polydimethylsiloxane with glycerol or aqueous ...
Incalcaterra R, Centi S, Barucci A, Magni G, Belli G, Pini R, Ratto F, Cavigli L, Mazzoni M, Carpi R, Borri C   +10 more
core   +1 more source