Results 111 to 120 of about 1,882,249 (253)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Icru Activity in the Field of Phantoms in Diagnostic-radiology

, 1992
The ICRU Report on `Phantoms and Computational Models in Radiation Therapy, Diagnosis and Protection' is presented. Different types of phantoms may be defined.
Wambersie, André, White, DR., SEMINAR ON DOSIMETRY IN DIAGNOSTIC RADIOLOGY   +2 more
core  

3D printed non-uniform anthropomorphic phantoms for quantitative SPECT

EJNMMI Physics
Background A 3D printing grid-based method was developed to construct anthropomorphic phantoms with non-uniform activity distributions, to be used for evaluation of quantitative SPECT images.
Lovisa Jessen, Johan Gustafsson, Michael Ljungberg, Selma Curkic-Kapidzic, Muris Imsirovic, Katarina Sjögreen-Gleisner   +5 more
doaj   +1 more source

Characterization of 3-Dimensional Printing and Casting Materials for use in Computed Tomography and X-ray Imaging Phantoms. [PDF]

J Res Natl Inst Stand Technol, 2020
Yunker BE, Holmgren A, Stupic KF, Wagner JL, Huddle S, Shandas R, Weir RF, Keenan KE, Garboczi E, Russek SE.   +9 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Depiction of obtained signal-to-noise ratios (SNR) imaging tumor phantoms at different depths under the tissue surface.

, 2018
Depiction of obtained signal-to-noise ratios (SNR) imaging tumor phantoms at different depths under the tissue surface.
Jens Waldeck (6102788), Carmen Wängler (3765850), Tim Kümmel (6102785), Mareike Roscher (3236160), Björn Wängler (2466943), Bernhard Müller (3459647), Edgar Schäfer (5007461), Daniel Schock-Kusch (447331), Matthias Rädle (546956), Frank Braun (1529212), Marc Pretze (3131406), Andreas Hien (5018576)   +11 more
core   +1 more source

Characterization of 3-Dimensional Printing and Casting Materials for use in Magnetic Resonance Imaging Phantoms at 3 T. [PDF]

J Res Natl Inst Stand Technol, 2020
Yunker BE, Stupic KF, Wagner JL, Huddle S, Shandas R, Weir RF, Russek SE, Keenan KE.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Physical imaging phantoms for simulation of tumor heterogeneity in PET, CT, and MRI: An overview of existing designs. [PDF]

Med Phys, 2020
Valladares A, Beyer T, Rausch I.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source