Results 61 to 70 of about 66,094 (288)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Enabling Complex Fibre Geometries Using 3D Printed Axon-Mimetic Phantoms

open access: yesFrontiers in Neuroscience, 2022
PurposeTo introduce a method to create 3D-printed axon-mimetic phantoms with complex fibre orientations to characterise the performance of diffusion magnetic resonance imaging (MRI) models and representations in the presence of orientation dispersion ...
Tristan K. Kuehn   +11 more
doaj   +1 more source

Learned Primal-dual Reconstruction

open access: yes, 2018
We propose the Learned Primal-Dual algorithm for tomographic reconstruction. The algorithm accounts for a (possibly non-linear) forward operator in a deep neural network by unrolling a proximal primal-dual optimization method, but where the proximal ...
Adler, Jonas, Öktem, Ozan
core   +1 more source

Seeing the phantom: A functional magnetic resonance imaging study of a supernumerary phantom limb

open access: yesAnnals of Neurology, 2009
AbstractObjectiveSupernumerary phantom limb (SPL) is a rare neurological manifestation where patients with a severe stroke‐induced sensorimotor deficit experience the illusory presence of an extra limb that duplicates a real one. The illusion is most often experienced as a somesthetic phantom, but rarer SPLs may be intentionally triggered or seen. Here,
Khateb, Asaid   +8 more
openaire   +7 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Advancing Phantom Fabrication: Exploring 3D-Printed Solutions for Abdominal Imaging Research

open access: yesApplied Sciences
Background: The development of novel medical imaging technologies and treatment procedures hinges on the availability of accurate and versatile phantoms.
Muris Becircic   +7 more
doaj   +1 more source

A Structured Cleaving Mesh for Bioheat Transfer Application

open access: yesIEEE Open Journal of Engineering in Medicine and Biology, 2020
Goal: The thermoregulation mechanism is a complex system that executes vital processes in the human body. Various models have been proposed to simulate the thermoregulatory response of an adult human to environmental stimuli.
Rohan Amare   +2 more
doaj   +1 more source

A multi-purpose phantom kit for magnetic particle imaging

open access: yesCurrent Directions in Biomedical Engineering, 2021
Phantoms are essential tools for the development and characterization of Magnetic Particle Imaging (MPI), an imaging technique that can quantitatively map the spatial distribution of magnetic nanoparticles (MNP).
Löwa Norbert   +5 more
doaj   +1 more source

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