Dasatinib: Effektive Alternative bei Imatinib-Resistenz und -Intoleranz [PDF]
, 2007 openalex +1 more source
Recent Advances in Metal‐Based Catalysts for Nitrile Hydration to Amides: Mechanistic Aspects
The Chemical Record, Volume 26, Issue 1, January 10, 2026.Amide vital functional group plays a key role in the composition of amide‐containing compounds, including peptides, proteins, and amino acids. Demand for innovative amide derivatives grows due to their crucial role in drug development. A cost‐effective method uses metal‐catalyzed hydration of nitriles to amides.
Fatima‐Ezzahraa Essebbar +3 more
wiley +1 more source
Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery
Advanced Healthcare Materials, Volume 15, Issue 2, 14 January 2026.This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo +3 more
wiley +1 more source
Treatment-free remission in FIP1L1-PDGFRA–positive myeloid/lymphoid neoplasms with eosinophilia after imatinib discontinuation [PDF]
, 2020 Georgia Metzgeroth +9 more
openalex +1 more source
Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao +4 more
wiley +1 more source
Pulmonary CirculationPulmonary tumor thrombotic microangiopathy (PTTM) is a severe and fatal disease that rapidly causes pulmonary hypertension (PH). While imatinib shows potential for treating PH related to PTTM, it remains unclear if imatinib should continue or be ...
Atsumasa Kurozumi +10 more
doaj +1 more source
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. [PDF]
, 2008 The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of ...
Aizenstein, Brian +9 more
core
Intermittent Target Inhibition With Dasatinib 100 mg Once Daily Preserves Efficacy and Improves Tolerability in Imatinib-Resistant and -Intolerant Chronic-Phase Chronic Myeloid Leukemia [PDF]
, 2008 Neil P. Shah +19 more
openalex +1 more source
Supplementary Methods from Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1) [PDF]
, 2023 Anne T. Nies +14 more
openalex +1 more source
Implanted Miniature Light Devices for Phototherapeutics
Advanced Therapeutics, Volume 9, Issue 1, January 2026.Modern phototherapeutics has many attractive features; however, the shallow penetration of light into skin and tissue is an inherent physical limitation that restricts usage to superficial sites of disease. To mitigate this major problem, researchers and clinicians are actively developing miniature implanted light devices that can be implanted within a
Hailey S. Sanders +5 more
wiley +1 more source