Results 231 to 240 of about 196,937 (296)
Privileged nitrogen heterocycles in anticancer drug discovery: recent advances on imidazole, indole, and pyrimidine scaffolds. [PDF]
RSC AdvGovindarajan M +6 more
europepmc +1 more source
Visible-light photocatalytic synthesis of imidazole-2-thiones in water using cobalt phthalocyanine. [PDF]
RSC AdvArman A +3 more
europepmc +1 more source
S375F mutation in Omicron variants causes destabilization and low production yield of SARS-CoV-2 recombinant Spike proteins. [PDF]
Protein Expr PurifDrew M +7 more
europepmc +1 more source
Synthesis of Imidazole-Based Medicinal Molecules Utilizing the Van Leusen Imidazole Synthesis
Pharmaceuticals, 2020 Imidazole and its derivatives are one of the most vital and universal heterocycles in medicinal chemistry. Owing to their special structural features, these compounds exhibit a widespread spectrum of significant pharmacological or biological activities ...
Dawei Zhang, Dawei Zhang, Zhengning Ma
exaly +2 more sources
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Journal of Medicinal Chemistry, 1975
A series of analogs of N-benzylimidazole was prepared and tested for hypolipidemic activity. Both plasma cholesterol and triglyceride-lowering activity were found in several members of the series. The most active compounds were N-3-methoxy-, N-4-methoxy-, and N-4-methylbenzylimidazole. Structure-activity relationships are discussed.
K H, Baggaley +5 more
openaire +2 more sources
A series of analogs of N-benzylimidazole was prepared and tested for hypolipidemic activity. Both plasma cholesterol and triglyceride-lowering activity were found in several members of the series. The most active compounds were N-3-methoxy-, N-4-methoxy-, and N-4-methylbenzylimidazole. Structure-activity relationships are discussed.
K H, Baggaley +5 more
openaire +2 more sources
American Pharmacy, 1991
Vaginal candidiasis is a common infection in women for which several effective therapeutic agents are currently available. Clotrimazole and miconazole were introduced in 1975, and both recently became available over the counter. These imidazole agents have largely replaced nystatin as primary therapy because of greater antifungal activity and shorter ...
C R, Lee, C A, McKenzie, A, Nobles
openaire +2 more sources
Vaginal candidiasis is a common infection in women for which several effective therapeutic agents are currently available. Clotrimazole and miconazole were introduced in 1975, and both recently became available over the counter. These imidazole agents have largely replaced nystatin as primary therapy because of greater antifungal activity and shorter ...
C R, Lee, C A, McKenzie, A, Nobles
openaire +2 more sources
The Significance of the Imidazole Ring in Anticonvulsant Activity of (Arylalkyl)imidazoles
Archiv der Pharmazie, 1988AbstractThe imidazole ring in nafimidone [1‐(2‐naphthyl)‐2‐(1‐imidazolyl)ethanone] was substituted with various groups to investigate the significance of the imidazole ring in anticonvulsant activity. For this purpose, some 2‐acetylnaphthalene derivatives and their reduction products were synthesized. Several N‐alkylation methods were used to prepare 2‐
ERTAN, MEVLÜT +3 more
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THE UTILIZATION OF IMIDAZOLES BY YEASTS
Canadian Journal of Microbiology, 1967Eleven imidazoles were tested singly as nitrogen sources for 62 strains of yeast. L-Histidine and histamine were used by most strains, D-histidine by some, and histidinol only by a few. Four yeasts grew on compounds containing nitrogen only in the imidazole ring.
LaRue, T. A., Spencer, J. F. T.
openaire +3 more sources