Results 101 to 110 of about 22,451 (231)

Quality by Design‐Based Development of a Robust LC Method for Simultaneous Estimation of Process‐ and Degradation‐Related Impurities in Rifapentine Drug Product for the Treatment of Active and Latent Tuberculosis

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT A precise, robust, and stability‐indicating liquid chromatographic (LC) method coupled with a photodiode array (PDA) detector was developed and validated for the quantitative estimation of rifapentine, an essential therapeutic agent for both active and latent tuberculosis (TB).
Siva Prasad Korikana, Sreenivasa Rao Battula, Naresh Konduru, Aravind Kurnool, Divya Kumar Vemuri, Venkata Lakshamana Sagar Dantinapalli   +5 more
wiley   +1 more source

Prolonged In Vivo Chemogenetic Generation of Hydrogen Peroxide by Endothelial Cells Induces Cardiac Remodelling and Vascular Dysfunction

Antioxidants
Increased levels of reactive oxygen species (ROS) are a hallmark of cardiovascular disease. ROS impact the function of proteins largely through thiol modification leading to redox signalling.
Melina Lopez, Niklas Herrle, Bardia Amirmiran, Pedro F. Malacarne, Julia Werkhäuser, Souradeep Chatterjee, Carine Kader, Victoria Jurisch, Xin Wen, Maedeh Gheisari, Katrin Schäfer, Christian Münch, Florian Leuschner, Ralf Gilsbach, Flávia Rezende, Ralf P. Brandes   +15 more
doaj   +1 more source

Stereoselective synthesis of (2S,3S,4Z)-4-fluoro-1,3-dihydroxy-2-(octadecanoylamino)octadec-4-ene, [(Z)-4-fluoroceramide], and its phase behavior at the air/water interface

Beilstein Journal of Organic Chemistry, 2008
BackgroundSphingolipids belong to the most important constituents of the membranes of eukaryotic cells. As intermediates in sphingolipid metabolism, sphingosine and its N-octadecanoyl-derivative, ceramide, exhibit a variety of biological functions. These
Gergana S. Nikolova, Günter Haufe
doaj   +1 more source

Synthesis of Sulfur Heterocycles by Palladium‐Catalyzed Cyclization

European Journal of Organic Chemistry, Volume 29, Issue 14, 15 April 2026.
In spite of the well‐known palladium thiophilicity, sulfur‐containing acyclic substrates may efficiently undergo several different kinds of palladium‐catalyzed cyclization processes leading to highly important sulfur heterocycles in one synthetic step. Advances in this challenging and stimulating field of research are presented in this review.
Bartolo Gabriele
wiley   +1 more source

Prolinuria: Defect in Intestinal Absorption of Imino Acids and Glycine

The Tohoku Journal of Experimental Medicine, 1966
Defective transport of imino acids and glycine in the intestine was demonstrated in a third case of prolinuria, basing upon the increased fecal excretion of imino acids and glycine after the oral loading with these amino acids.
T, Morikawa, K, Tada, T, Ando, T, Yoshida, Y, Yokoyama, T, Arakawa   +5 more
openaire   +3 more sources

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

2D Metal‐Organic Frameworks for High‐Performance Solid‐State Electrolytes: A Comprehensive Review

Advanced Science, Volume 13, Issue 20, 9 April 2026.
In this review, we elucidate the intrinsic advantages, synthetic methodologies, structural characteristics, ion‐transport mechanisms and performance optimization strategies while highlighting representative material systems and applications of 2D MOFs for electrolyte applications.
Changchun Ai, Yuan Tian, Yilei Shu, Peng Hang, Wentao Li, Yiling Yao, Huijuan Guo, Qun Yi, Hongmei Dai   +8 more
wiley   +1 more source

Operational stability of mixed Sn–Pb perovskite solar cells: Mechanisms, mitigation strategies, and perspectives

Bulletin of the Korean Chemical Society, Volume 47, Issue 4, Page 416-428, April 2026.
This review consolidates mechanisms and solutions for mixed Sn–Pb perovskite solar cells. It identifies Sn2+ oxidation, iodine generation, and interfacial defects as primary instabilities. It discusses progress in additives, interface passivation, alternative hole transport layers, and solvent engineering as well as future directions for achieving long‐
Lei Chen, Kai Zhu
wiley   +1 more source

Smart Materials for Dirty Waters: Reversible Aerogels Unlock Closed‐Loop Heavy Metal Remediation

Small Science, Volume 6, Issue 4, April 2026.
Reversible chitosan–lignin aerogels are developed for efficient heavy metal removal (Cu2+, Pb2+, and Zn2+) from contaminated water, combining high adsorption capacity, recyclability, solvents, and pH stability. The aerogels also demonstrate catalytic activity in Chan–Lam crosscoupling reactions, showcasing their potential for sustainable water ...
Davide Gentile, Dario Allevi, Massimo Zambito Marsala, Lucrezia Criscuolo, Maurizio Galimberti, Vincenzina Barbera   +5 more
wiley   +1 more source

Peri‐Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Disruption of astrocytic glycogen metabolism, induced by glycogen phosphorylase inhibition (DAB) or genetic deficiency of GYS1 (GYS1Nestin‐KO and GYS1Gfap‐KO), reduces lactate availability to pericytes and impairs microvascular function. This metabolic deficit leads to pericyte‐associated capillary constriction, reduced cerebral blood flow, and ...
Gokhan Uruk, Buket Donmez‐Demir, Sinem Yilmaz‐Ozcan, Canan Cakir‐Aktas, Aslihan Taskiran‐Sag, Gokce Gurler, Jordi Duran, Joan J. Guinovart, Otto Baba, Tsuyoshi Morita, Hulya Karatas, Turgay Dalkara, Muge Yemisci   +12 more
wiley   +1 more source