Dissecting the Chemical and Thermal Stabilities of Tetrads in G-Quadruplexes to Derive a Structure-Activity Relation for a Thrombin-Binding DNA G-Quadruplex Aptamer. [PDF]
ChembiochemExtended variants of the G‐quadruplex thrombin binding aptamer exhibit differential anticoagulation activities. We show that 3’ terminal extensions increase nuclease resistance, while variations in thermal stability directly impact activity. Hydrogen exchange nuclear magnetic resonance spectroscopy (NMR) report on thermodynamic properties of the base ...
Wirmer-Bartoschek J +3 more
europepmc +2 more sources
Microbial Cell, 2022 Pseudomonas aeruginosa inhabits diverse environmental niches that can have varying nutrient composition. The ubiquity of this organism is facilitated by a metabolic strategy that preferentially utilizes low-energy, non-fermentable organic acids, such as ...
Ronnie L. Fulton, Diana M. Downs
doaj +1 more source
Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop [PDF]
, 2018 Nucleic acids can form noncanonical four-stranded structures called G-quadruplexes. G-quadruplex-forming sequences are found in several genomes including human and viruses.
Anh Tuân Phan +6 more
core +2 more sources
High-Resolution Three-Dimensional NMR Structure Of The KRAS Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation [PDF]
, 2017 Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4).
Ivashchenko, S. +5 more
core +2 more sources
Base-pair Opening Dynamics of Nucleic Acids in Relation to Their Biological Function
Computational and Structural Biotechnology Journal, 2019 Base-pair opening is a conformational transition that is required for proper biological function of nucleic acids. Hydrogen exchange, observed by NMR spectroscopic experiments, is a widely used method to study the thermodynamics and kinetics of base-pair
Seo-Ree Choi +5 more
doaj +1 more source
Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome [PDF]
, 2016 open8The long terminal repeat (LTR) of the proviral human immunodeficiency virus (HIV)-1 genome is integral to virus transcription and host cell infection.
core +1 more source
Inorganics, 2023 Octahedral chiral-at-metal Ir(III) complexes exhibit excellent structural stability and stereoselectivity in asymmetric synthesis. Selectively oxidative dehydrogenation of amino acids could be achieved by exploiting such complexes as chiral templates ...
Suyang Yao +4 more
doaj +1 more source
Mechanistic insights into an engineered riboswitch: a switching element which confers riboswitch activity [PDF]
, 2010 While many different RNA aptamers have been identified that bind to a plethora of small molecules only very few are capable of acting as engineered riboswitches.
Duchardt-Ferner, Elke +6 more
core +1 more source
Effect of sulphite ions on the proline and polyamine content in the bean Phaseolus vulgaris
Acta Societatis Botanicorum Poloniae, 2014 The influence of sulphite (0.0125-0.2%) on changes in the levels of free proline, protein bound proline and hydroxyproline and of free polyamines in the roots and leaves of two cultivars of beans (Phaseolus vulgaris) differing in sensitivity to these ...
Piotr Karolewski, Nina I. Shevyakowa
doaj +1 more source
Polish Journal of Food and Nutrition Sciences, 2021 Previous studies reported hydrolyzed collagen increase cell proliferation and migration involved in the wound repair process. Nevertheless, the knowledge related with wound repair mechanism of hydrolyzed collagen from salmon skin (HCSS) has not been ...
Wanwipha Woonnoi +5 more
doaj +1 more source