Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens [PDF]
, 2013 There is accumulating evidence that the nucleus accumbens (NAc) has an important role in the pathophysiology of depression. As the NAc is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of ...
A Dranovsky +32 more
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Preclinical discovery of duloxetine for the treatment of depression [PDF]
, 2012 Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María +4 more
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Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia [PDF]
, 2016 The use of tyrosine kinase inhibitors (TKI), including nilotinib, has revolutionized the treatment of chronic myeloid leukemia (CML). However current unmet clinical needs include combating activation of additional survival signaling pathways in ...
Arbiser +47 more
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Research in Pharmaceutical Sciences, 2016 High-performance liquid chromatography (HPLC) methods employing ultraviolet (UV) detector are not sufficiently sensitive to measure the low plasma concentrations following single oral dose of imipramine.
Mahboubeh Rezazadeh, Jaber Emami
doaj
Antidepressants in the Management of Chronic Pain Syndromes [PDF]
, 1990 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90213/1/j.1875-9114.1990.tb02582.x ...
Chaffee, Betty J., Egbunike, Ifeanyi G.
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THE EFFECT OF CHLORPROMAZINE, METYRAPONE, IMIPRAMINE AND SKF 525‐A ON THE HEPATIC FIRST PASS ELIMINATION OF PROPRANOLOL IN THE PITHED RAT [PDF]
, 1982 HE Barber, N.R. Kitteringham, J C Petrie
openalex +1 more source
The Effect of Sympathetic Antagonists on the Antidepressant Action of Alprazolam
Libyan Journal of Medicine, 2008 Alprazolam is an anti-anxiety drug shown to be effective in the treatment of depression. In this study, the effect of sympathetic receptor antagonists on alprazolam–induced antidepressant action was studied using a mouse model of forced swimming ...
Gorash ZM +4 more
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ヘキサナール刺激でドーパミンを放出した PC12 細胞のドーパミンの再蓄積作用 [PDF]
, 2017 すべての食品に匂い（香り）がある．食品に含まれる匂い（香り）物質は，食品中の栄養素と同様に体内に取り込まれ，生理作用を示すと考えている． ヘキサナールは炭素数6 の直鎖アルデヒドであり，植物特有の新鮮な香りを構成している物質の1 つである． これまでに，私たちは，ヘキサナールがラット脳線条体切片及びラット副腎褐色細胞腫（PC12）細胞からのドーパミン放出を促進することを報告している． ドーパミンを放出した細胞は，次の刺激に応答するために，細胞内にドーパミンを再蓄積する必要がある． 本研究では ...
Kobayashi, Yoko, 小林, 葉子
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Determination of fluphenazine, related phenothiazine drugs and metabolites by combined high-performance liquid chromatography and radioimmunoassay. [PDF]
, 1981 Antibodies have been produced in rabbits immunized with a fluphenazine succinate-human serum albumin conjugate. By radioimmunoassay it is possible to quantify fluphenazine (FPZ), related phenothiazine drugs and several of their metabolites at the ...
Goldstein, SA, Van Vunakis, H
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