Results 81 to 90 of about 51,042 (305)

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

In vivo and in vitro effect of imipramine and fluoxetine on Na+,K+-ATPase activity in synaptic plasma membranes from the cerebral cortex of rats

Brazilian Journal of Medical and Biological Research, 2001
The effects of in vivo chronic treatment and in vitro addition of imipramine, a tricyclic antidepressant, or fluoxetine, a selective serotonin reuptake inhibitor, on the cortical membrane-bound Na+,K+-ATPase activity were studied.
L.M. Zanatta, F.C. Nascimento, S.V.T. Barros, G.R.R.S. Silva, A.I. Zugno, C.A. Netto, A.T.S. Wyse   +6 more
doaj   +1 more source

Delphi Consensus Among French Obesity Experts on Clinical Recommendations for Drug Prescription in Patients With Severe Obesity

Obesity Reviews, EarlyView.
ABSTRACT Introduction Although the physiologic alterations seen in obesity often affect the pharmacokinetics and pharmacodynamics of drugs, most clinical trials do not consider these aspects specifically for this population. To date, there is no list of potentially inappropriate medications for patients living with obesity. The aim of this study was to
Sarah Berdot, Germain Perrin, Emmanuel Disse, Armelle Arnoux, Eric Bertin, Anne‐Laure Borel, Marie‐Claude Brindisi, Arnaud De Luca, Edouard‐Jules Laforgue, Jean‐Daniel Lalau, Yann Matussiere, Emilie Montastier, Agnès Sallé, Bérénice Segrestin, Valentine Suteau, French Hospital Expert Panel, Sebastien Czernichow, Brigitte Sabatier   +17 more
wiley   +1 more source

Immunomodulatory effects of photodynamic therapy for skin cancer: Potential strategies to improve treatment efficacy and tolerability

Photochemistry and Photobiology, EarlyView.
Photodynamic therapy (PDT) is a nonscarring treatment modality that is widely used for skin cancers and early squamous precursor lesions. PDT was previously thought to work primarily by killing cancer cells directly (via apoptosis or necrosis). However, more recent work indicates that a significant mechanism for PDT is the stimulation of anti‐cancer ...
Mark P. Ortenzio, Sanjay Anand, Jeffrey B. Travers, Edward V. Maytin, Craig A. Rohan   +4 more
wiley   +1 more source

Incontinência do choro e infarto protuberancial unilateral Incontinence of crying and unilateral pontine infarct

Arquivos de Neuro-Psiquiatria, 1995
O presente estudo trata do caso de um paciente que apresentou incontinência do choro e hemiplegia direita por infarto ventroprotuberancial paramediano detectado pela RNM.
Ricardo de Oliveira-Souza, Wagner Martignoni de Figueiredo, Pedro ângelo Andreiuolo   +2 more
doaj   +1 more source

The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT This scoping review investigates the association between ABCB1 polymorphisms and antidepressant efficacy in humans. A systematic search identified 630 records, of which 58 met the inclusion criteria, resulting in 42 unique studies (five randomised controlled trials (RCTs), two randomised studies (non‐RCTs), 30 prospective cohort studies, three
Sofie Voss Thorsen, Cille Bülow, Kim Dalhoff, David Peick Sonne   +3 more
wiley   +1 more source

Decrease of vanillin sucrose intake by victorious and defeated mice: development of anhedonia? [PDF]

, 2007
Hedonic reactions to various rewards play a key role in various forms of motivated behavior. The influence of repeated experience of social victories or defeats in daily agonistic interactions between male mice on voluntary consumption of vanillin ...
Damira F. Avgustinovich, Irina L. Kovalenko, Natalia N. Kudryavtseva, Natalia P. Bondar   +3 more
core   +1 more source

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology‐Driven Delivery Strategies

Fundamental &Clinical Pharmacology, Volume 39, Issue 5, October 2025.
ABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
Dominique Mesquita e Silva, Laís de Souza Lacerda, Andrea de Souza Andrioli, Wilson Rodrigues Braz, Lara Melo Campos, Mayara Rodrigues Brandão de Paiva, Frederico Pittella, Rodrigo Luiz Fabri, Guilherme Diniz Tavares   +8 more
wiley   +1 more source

Experience Of Medical Treatment With Desmopressin And Imipramine In Children With Severe Primary Nocturnal Enuresis In Taiwan

Research and Reports in Urology, 2019
Thomson T Tai,1,2 Brent T Tai,2,3 Yu-Jun Chang,2 Kuo-Hsuan Huang4,5 1Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA; 2Department of Epidemiology and Biostatistics, Changhua Christian Hospital, Changhua, Taiwan; 3Burrell College ...
Tai TT, Tai BT, Chang YJ, Huang KH
doaj  

The Calbindin-D28k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action [PDF]

, 2011
Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action.
Amnon Hoffman, Chaim Gilon, Galila Agam, Itshak Levi, Joseph Fanous, Miriam Eisenstein, Orna Almog, Yael Askira, Yftah Talgan   +8 more
core   +1 more source