Results 91 to 100 of about 1,178,558 (261)

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Importance of immature platelet fraction as predictor of immune thrombocytopenic purpura. [PDF]

Pak J Med Sci, 2016
Background and Objective: Immune thrombocytopenic purpura (ITP) is a clinical syndrome in which a decreased number of circulating platelets (thrombocytopenia) manifests as a bleeding tendency, easy bruising (purpura) or extravasation of blood from capillaries into skin and mucous membranes (petechiae). The diagnosis of ITP can be made clinically on the
Naz A, Mukry SN, Shaikh MR, Bukhari AR, Shamsi TS.   +4 more
europepmc   +3 more sources

Role of platelet count, platelet indices, and immature platelet fraction as potential markers for monitoring platelet reactivity in patients with acute coronary syndrome undergoing percutaneous coronary intervention [PDF]

The acute coronary syndrome is an acute manifestation of coronary heart disease, which is caused by a ruptured plaque of the coronary artery, thus forming a thrombus formation and resulting in myocardial infarction.
Puspa Wardhani, -, Ikke Nanda Amalia, Yetti Hernaningsih   +2 more
core   +1 more source

Time course trends of platelet parameters in each group from the first to tenth days of illness.

, 2021
Box and whisker plots show the time course trends of platelet parameters in each group from the first to tenth days of illness. Boxes show the median and interquartile values, whiskers represent the upper and lower adjacent values and dots indicate ...
Michio Yasunami (201944), Dorcas Valencia Umipig (11563931), Emi Kitashoji (760654), Chris Fook Sheng Ng (5105285), Ikkoh Yasuda (8061647), Kentaro Sakashita (11563940), Rontgene M. Solante (11563935), Ana Ria Sayo (11563938), Motoi Suzuki (289165), Nobuo Koizumi (276538), Koya Ariyoshi (7877), Ferdinand De Guzman (11632041), Chris Smith (61664), Nobuo Saito (2266051)   +13 more
core   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

HUBUNGAN IMMATURE PLATELET FRACTION DENGAN PERUBAHAN HITUNG TROMBOSIT PADA PASIEN DEMAM BERDARAH DENGUE Penelitian Analisis Observasional Cross-Sectional Di Divisi Tropik Infeksi Rumah Sakit Umum Daerah Dr Soetomo Surabaya [PDF]

, 2017
Latar Belakang : Perjalanan klinis penyakit DBD sulit diprediksi. Perbaikan hitung trombosit adalah salah satu parameter pemulihan pada pasien DBD. Immature platelet fraction dapat digunakan untuk memperkirakan perubahan hitung trombosit 1-2 hari ...
RORI INDRAS PUSPITA, NIM010980243
core   +1 more source

A Neutrophil Membrane‐Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age‐Dependent Perioperative Neurocognitive Disorders

Advanced Science, EarlyView.
This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang, Jiahui Cheng, Huan Xu, Qiang Zhang, Xiao Zhang, Ye Liu, Yizhe Zhang, Wanbing Dai, Zhi Xiong, Linghuan Guo, Lingling Xu, Wen Wang, Xin Xu, Yan Zhou, Weifeng Yu, Bo Li, Diansan Su, Daxiang Wen   +17 more
wiley   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Indeks Platelet Dan Immature Platelet Fraction (IPF) Pada Pasien Sindroma Koroner Akut [PDF]

, 2019
Latar Belakang : Sindroma koroner akut (SKA) dibedakan menjadi ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI) dan unstable angina. Platelet berperan penting dalam patogenesis SKA.
Endah Indriastuti
core