Reticulated Platelets—Which Functions Have Been Established by in Vivo and in Vitro Data? [PDF]
Cells, 2021 Reticulated platelets (RP) are the youngest platelet fraction released into the circulation. These immature platelets have increased RNA content, a larger cell volume, more dense granules, higher levels of surface activation markers and are thought to be
Daniel Duerschmied +2 more
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Sorting and Magnetic-Based Isolation of Reticulated Platelets From Peripheral Blood
Platelets, 2021 Reticulated Platelets (RPs) are large, RNA-rich, prothrombotic and hyperactive platelets known to be elevated in high-risk populations such as diabetics and patients with acute coronary syndrome.
Christian Weber +2 more
exaly +3 more sources
A transgenic mouse model for reticulated platelet detection reveals expansion after myocardial ischemia/reperfusion [PDF]
Blood Vessels, Thrombosis & Hemostasis: Reticulated platelets are newly formed, RNA-rich platelets with heightened reactivity. Although elevated levels are observed after myocardial ischemia/reperfusion injury, their functional contributions to postischemic pathology remains poorly defined ...
Muataz Ali Hamad +12 more
doaj +4 more sources
Reticulated Platelets and Immature Platelet Fraction: Clinical Applications and Method Limitations [PDF]
International Journal of Laboratory Hematology, 2020 AbstractSo‐called “reticulated” or “immature platelets,” which are newly released into the circulation, are more reactive than mature platelets, contain more RNA, and can be counted using flow cytometry after staining with thiazole orange or using some fully automated hematology analyzers, albeit with numerical disagreement.
Mario Plebani, Mauro Buttarello
exaly +6 more sources
Mesenchymal Stem Cells and Reticulated Platelets: New Horizons in Multiple Myeloma [PDF]
Hematology ReportsMultiple myeloma (MM) is a malignant plasma cell disorder characterized by the accumulation of abnormal plasma cells in the bone marrow. Mesenchymal stem cells (MSCs) and reticulated platelets (RPs) have been implicated in the pathogenesis of MM.
Cristian Alejandro Mera Azaín +3 more
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Reticulated Platelets and an Optimal Model for Differentiating Thrombocytopenia Etiologies [PDF]
eJHaemObjectives This study aimed to investigate the clinical value of reticulated platelets (RtcPLT) percentage derived from an automated hematology analyzer in differentiating thrombocytopenia due to peripheral etiology from decreased bone marrow production (
Tung Thanh Tran +5 more
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Immature platelet fraction and reticulated platelet parameters as potential indicators of bone-marrow-related platelet production in dogs and cats: A scoping review. [PDF]
PLoS ONEBackgroundEvaluating bone marrow is an invasive and expensive procedure that frequently necessitates sedation or anesthesia in dogs and cats. The immature platelet fraction (IPF(and related immature or reticulated platelet parameters, has been suggested ...
Mahmood Ahmadi-Hamedani, Kimia Satari
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Platelet subpopulations and contribution to hemostasis [PDF]
Blood SciencePlatelets are traditionally considered a homogeneous population of anucleate cells derived from megakaryocytes, primarily responsible for hemostasis and thrombus formation.
Rouba Z. Banimifrig, Fahad S. Alshehri
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Platelet Subpopulations in Health and Disease: Heterogeneity, Clinical Associations, and Therapeutic Targeting [PDF]
CellsPlatelets are often described in simple terms as small anucleate cells that mediate hemostasis, but studies over more than half a century have shown that circulating platelets are heterogeneous in size, density, age, and functional responses.
Deepa Gautam +2 more
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The Prognostic Value of Reticulated Platelets in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis [PDF]
Frontiers in Cardiovascular Medicine, 2020 Background: Reticulated platelets (RPs) represent the young population in the circulating platelet pool, indicating platelet turnover. Preliminary studies suggested circulating levels of RPs were associated with cardiovascular events (CVEs) in patients ...
Yihan Zhao +5 more
doaj +2 more sources