Characterizing mouse platelet heterogeneity across diverse disease models using spectral flow cytometry and high-dimensional analysis [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Routine platelet assessment based on count and mean platelet volume overlooks heterogeneity of platelet subpopulations that influence disease outcomes.
Deepa Gautam +8 more
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Platelets, 2018 Platelets are recognized to be physiologically and functionally heterogeneous. An example of the diversity in reactivity is the formation of a distinct subpopulation of procoagulant phosphatidylserine (PS)-exposing platelets upon activation. Platelet age
Emily C. Reddy +4 more
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Cutaneous Intravascular Large B-Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis [PDF]
Case Reports in Dermatological MedicineIntravascular large B-cell lymphoma (IVLBCL) is an uncommon and aggressive subtype of non-Hodgkin lymphoma defined by the proliferation of large malignant B cells confined within small blood vessels.
Shamsu S. Bello +3 more
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A multi-color flow cytometric method for characterizing murine reticulated platelets using SYTO 13 [PDF]
PlateletsReticulated platelets (RP) are immature platelets with heightened RNA content. An increased level of RP in the circulation is associated with various pathological conditions.
Muataz Ali Hamad +7 more
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Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies. [PDF]
Arterioscler Thromb Vasc Biol, 2017 Objective— Aspirin together with thienopyridine P2Y 12 inhibitors, commonly clopidogrel, is a cornerstone of antiplatelet therapy.
Armstrong PC +7 more
europepmc +2 more sources
PlateletsIn comparison to mature platelets, reticulated platelets (RPs) are newly released from the bone marrow and exhibit a larger size, higher reactivity, and a greater quantity of RNA, and can be an agile indicator of platelet turnover.
Yuxin Zhang +3 more
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Applications of Extended Platelet Profiles in Clinical Practice [PDF]
DiseasesThrombocytopenia is a frequent complication of patients presenting emergently across the world for a wide array of etiologies. From patients who develop thrombocytopenia due to invasive neoplastic disease affecting the bone marrow to patients who develop
Yi Yuan Zhou, Robert W. Maitta
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The silent saboteurs: reticulated platelets in coronary artery disease. [PDF]
Eur Heart JPark HE, Cameron SJ.
europepmc +4 more sources
Impact of Reticulated Platelets on Platelet Reactivity in Neonates [PDF]
Journal of Cardiovascular Pharmacology and Therapeutics, 2021 Neonatal megakaryopoiesis and platelet turnover form a developmentally unique pattern by generating a pool of newly released reticulated platelets from the bone marrow into the circulation. Reticulated platelets are more reactive and hyperaggregable compared to mature platelets, due to their high residual mRNA content, large size, increased expression ...
openaire +2 more sources
Platelet number and function in response to a single intravenous dose of vincristine
Journal of Veterinary Internal Medicine, 2021 Background Vincristine might increase circulating platelet numbers but the functional capacity of these newly released platelets is unknown. Objective To evaluate and compare the functionality of mature and immature (reticulated) platelets after a single
Erin C. Allen +4 more
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