Results 131 to 140 of about 1,178,558 (261)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Immature platelet fraction as a clinical predictor for enhanced platelet recovery in patients with dengue fever

One Health Bulletin
Objective: To evaluate the potential of immature platelet fraction (IPF) as a predictor of increased platelets in dengue fever patients. Methods: A cross-sectional study was conducted. We analyzed the medical records of confirmed dengue patients who were
I Ketut Agus Somia, Cokorda Agung Wahyu Purnamasidhi, Dewa Ayu Fony Prema Shanti, Giovanca Verentzia Purnama, I Komang Hotra Adiputra   +4 more
doaj   +1 more source

From reticulated platelets to immature platelet fraction: structure, function, and clinical applications

Platelets
In comparison to mature platelets, reticulated platelets (RPs) are newly released from the bone marrow and exhibit a larger size, higher reactivity, and a greater quantity of RNA, and can be an agile indicator of platelet turnover. The transcriptome associated with platelet function is significantly upregulated in RPs, which is a possible explanation ...
Yuxin Zhang, Ziyun Wang, Pan Zhou, Hongwei Zhang   +3 more
openaire   +3 more sources

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

ASOSIASI ANTARA TINGKAT KEPARAHAN SEPSIS DENGAN IMMATURE PLATELET FRACTION Penelitian Analitik Observasional Cross-Sectional Di Instalasi Rawat Inap Penyakit Dalam RSUD Dr. Soetomo Surabaya [PDF]

, 2017
Immature platelet fraction (IPF) adalah parameter hematologi yang mengukur proporsi trombosit muda dengan jumlah trombosit total. Pada sepsis, IPF diduga meningkat akibat megakaryopoiesis yang diinduksi sitokin proinflamasi bersamaan dengan ...
MUTIARA RIZKI HARYATI, NIM010980245
core   +1 more source

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

The association between immature platelet count and clinical characteristics in pediatric immune thrombocytopenia

Research and Practice in Thrombosis and Haemostasis
Background: Despite the increasing number of treatments for immune thrombocytopenia (ITP), there are no established laboratory predictors of treatment response.
Emily M. Harris, Michele P. Lambert, Amanda Grimes, Jenny Despotovic, Jennifer A. Rothman, Caitlyn McComb, Brian Guedes, Susan Kirk, Abinaya Arulselvan, Matthew Basara, Brenna Cannon, Sam King, Andrew L. Frelinger, Nan Chen, Wendy B. London, Rachael F. Grace   +15 more
doaj   +1 more source

Changes in the immature platelet fraction within ageing platelet concentrates

Journal of Thrombosis and Haemostasis, 2008
Albanyan, A, Murphy, M, Wilcock, M, Harrison, P   +3 more
openaire   +4 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source