Results 231 to 240 of about 1,178,558 (261)

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Immature Platelet Fraction in Diabetes Mellitus and Metabolic Syndrome

Thrombosis Research, 2013
Dysregulated platelet-endothelial interaction plays a pivotal role in atherothrombotic events in patients with diabetes mellitus (DM). Immature platelet fraction (IPF) is a hematologic parameter of automated hematologic analyzer and is related to platelet size and cytoplasmic RNA contents. It reflects thrombopoiesis and also is often used as the marker
Jaewoo Song, Seung Jun Choi
exaly   +5 more sources

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Immature Platelet Fraction and Its Kinetics in Neonates

Journal of Pediatric Hematology/Oncology, 2022
Thrombocytopenia is a common abnormality encountered in the neonatal period, and immature platelet fraction (IPF) may be an informative indicator of thrombopoiesis; however, data on IPF in neonates are scarce. To define reference intervals (RIs) and factors affecting IPF in neonates, we measured the IPF of 533 consecutive neonates.
Jun, Kobayashi, Yuka, Takezawa, Shoji, Saito, Noriko, Kubota, Kazuo, Sakashita, Yozo, Nakazawa, Yumiko, Higuchi, Minoru, Tozuka, Fumihiro, Ishida   +8 more
openaire   +2 more sources

Immature Platelet Fraction and the Extent of Coronary Artery Disease: A Single Centre Study [PDF]

Atherosclerosis, 2017
BACKGROUND AND AIMS: Immature platelet fraction (IPF) represents the quote of younger and larger sized circulating platelets, a potential marker of platelet reactivity and major cardiovascular events.
Giuseppe De Luca, Monica Verdoia, Paolo Marino   +2 more
exaly   +2 more sources

Establishment of Reference Interval for Immature Platelet Fraction

International Journal of Laboratory Hematology, 2013
SummaryIntroductionImmature platelet fraction (IPF) is a parameter for reticulated platelets. A high percentage IPF (%‐IPF) is indicative of consumptive or recovering thrombocytopenic disorders in contrast to a low %‐IPF seen in aplastic states. Absolute IPF (A‐IPF) specifically reflects the number of immature platelets in circulation. This study aimed
Mina Hur, S N Hong, H -W Moon
exaly   +3 more sources

Assessment of an Immature Platelet Fraction (IPF) in Peripheral Thrombocytopenia

British Journal of Haematology, 2004
SummaryA new automated method to reliably quantify reticulated platelets, expressed as the immature platelet fraction (IPF), has been developed utilizing the XE‐2100 blood cell counter with upgraded software (Sysmex, Kobe, Japan). The IPF is identified by flow cytometry techniques and the use of a nucleic acid specific dye in the reticulocyte/optical ...
Samuel J Machin, Shinichiro Oguni
exaly   +3 more sources

The Effect of Storage on the Clinical Utility of the Immature Platelet Fraction

Hematology, 2009
The immature platelet fraction (%IPF) is a highly utilised new parameter in the full blood count (FBC) profile. It is a measure of the number of reticulated platelets and hence provides information on platelet transfusion requirements. It is common practice to measure %IPF values on blood samples that are several hours old, however unlike the well ...
exaly   +3 more sources

Evaluation of the immature platelet fraction as an indicator of platelet recovery in dengue patients

International Journal of Laboratory Hematology, 2013
Summary Introduction Thrombocytopenia is a common complication in many disorders (such as aplastic anemia, ITP , dengue fever,), the etiology being multifactorial. Immature platelet fraction ( IPF
T, Dadu, K, Sehgal, M, Joshi, S, Khodaiji   +3 more
openaire   +2 more sources