Results 241 to 250 of about 237,408 (289)

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Treatment of Leukemia Cutis Secondary to T-Cell Prolymphocytic Leukemia With Upadacitinib. [PDF]

EJHaem
Fraser K, Langille C, Chen LYC, Purdy K.
europepmc   +1 more source

Development of Biodegradable Talc‐Filled PBAT/PLA and PBSA/PBAT Binary Blend Films: Effects of Multilayer Architecture and Uniaxial Orientation on Performance

Polymer Engineering &Science, EarlyView.
PBAT‐based PLA and PBSA blend films were developed in single‐ and tri‐layer structures with talc and processed via blown film extrusion followed by uniaxial stretching. Multilayer design and MDO significantly enhanced mechanical strength, stiffness, barrier, and UV resistance through chain orientation and strain‐induced crystallization.
Debarshi Nath, Matias Menossi, Ehsan Pesaranhajiabbas, Amar K. Mohanty, Manjusri Misra   +4 more
wiley   +1 more source

Profound thrombocytopenia and transient leucoerythroblastosis following hip fracture surgery. [PDF]

BMJ Case Rep
Eshaghpour A, Bell C, Nazy I, Warkentin TE.   +3 more
europepmc   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

Microscopic giant platelets versus automated mean platelet volume for severity assessment in COVID-19. [PDF]

Medicine (Baltimore)
Coşkuner MA, Uyar S, Aykaş F, Kök M, Köker G, Güllü Koca T, Koca N.   +6 more
europepmc   +1 more source

The Emerging Role of China in the Innovation, Individualization, and Translation of Antiviral Therapeutics for Chronic Hepatitis B

Portal Hypertension &Cirrhosis, EarlyView.
This perspective outlines China's contributions toward functional‐cure‐oriented antiviral therapies for chronic hepatitis B, summarizing key clinical data on bepirovirsen and domestic drug pipelines with balanced coverage of both promising and disappointing trial results.
Dandan Weng, Zhujun Cao, Qing Xie
wiley   +1 more source

First evidence of the circulation of induced pluripotent stem cell-derived platelets in humans. [PDF]

Stem Cells Transl Med
Takao K, Kumagae Y, Kanda J, Hirose H, Konno H, Inoue T, Sato Y, Hazama Y, Hasegawa M, Asami A, Nishimura M, Sawaguchi A, Takaori-Kondo A, Akamatsu K.   +13 more
europepmc   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source