Results 51 to 60 of about 247,213 (311)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Immobilization-Free Photoelectrochemical Aptasensor for Atrazine Based on Bifunctional Graphene Signal Amplification and a Controllable Sulfhydryl-Assembled BiOBr/Ag NP Microinterface

, 2023
Immobilization-free sensors (IFSs), with no requirement of fixing the recognition element to the electrode surface, have received increasing attention due to their unique advantages of reusable electrodes, not being limited by the load of the recognition
Bingyu Du (13966101), Ziwei Zhang, Meichuan Liu, Ye Feng, Ye Feng (196094), Ziwei Zhang (2029975), Meichuan Liu (1606726), Guangqiu Lu (15419680), Guangqiu Lu, Bingyu Du, Huanhuan Sun, Huanhuan Sun (5082386)   +11 more
core   +1 more source

Water-Soluble Ionic Metal–Organic Polyhedra as a Versatile Platform for Enzyme Bio-immobilization

, 2023
Metal–organic polyhedra (MOPs) can act as elementary structural units for the design of modular porous materials; however, their association with biological systems remains greatly restricted by their typically low stabilities and solubilities in water ...
Purna K. Boruah (6334406), Yuta Ohtsubo (15508485), Benjamin Le Ouay (7349381), Rin Kunitomo (15508482), Clémence Sicard (1749472), Ryosuke Minami (15508479), Kohei Torikai (1581406), Ryo Ohtani (2101120), Masaaki Ohba (1536271)   +8 more
core   +2 more sources

Effects of 2 weeks lower limb immobilization and two separate rehabilitation regimens on gastrocnemius muscle protein turnover signaling and normalization genes

BMC Research Notes, 2012
Background Limb immobilization causes a rapid loss of muscle mass and strength that requires appropriate rehabilitation to ensure restoration of normal function.
Nedergaard Anders, Jespersen Jakob G, Pingel Jessica, Christensen Britt, Sroczynski Nicholas, Langberg Henning, Kjaer Michael, Schjerling Peter   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Advances in immobilization of radionuclide wastes by alkali activated cement and related materials

, 2022
Nuclear power is seen a significant part of new energy industry because of the low carbon emission feature and high efficiency. Safe and reliable immobilization of radionuclide wastes from nuclear power station is important for its operation.
Zhang, Zuhua, Zhu Yingcan, Zheng, Zhao, Deng, Yulin, Shi, Caijun   +4 more
core   +1 more source

Cesium immobilization in metakaolin-based geopolymers elucidated by 133Cs solid state NMR spectroscopy [PDF]

, 2021
Geopolymers are promising candidates for nuclear-waste immobilization, and more specifically for the immobilization of radioactive cesium. Low-Si metakaolin-based geopolymers cured at temperatures of 40°C in the presence of Cs ions generate a mixture of ...
Yaron, Schlosser, Amir, Goldbourt, Yonatan, Harnik, Michal, Arbel Haddad   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Immobilization of enzymes on magnetic particles

, 2006
Item not available in this repository.Magnetic particles have been increasingly used as carriers for binding proteins, enzymes, and drugs. Such immobilization procedures for proteins, enzymes, antibodies, and other biologically active compounds have a ...
Michael Trevan, Peter Kopčanský, De Sequeira, A, Trevan, M, Saiyed, Zainul M., Koneracká, M, Milan Timko, Saiyed, Z. M, Koneracká, Martina, Kopčanský, Peter, Chenyl Nynitapal Ramchand, de Sequeira, Anil, Ramchand, C. N, Martina Koneracká, Trevan, Michael, Ramchand, Chenyl Nynitapal, Anil de Sequeira, Timko, M, Zainul M. Saiyed, Timko, Milan, Kopcanský, P   +20 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source