Results 31 to 40 of about 44,060 (259)

Effect of Vitamin C, as an Antioxidant, on Immobilization-Induced Changes in Sexual Behavior and Sperm Count in Male Mice [PDF]

open access: yesJournal of Genetic Resources, 2016
Sexual behavior in males is vulnerable to stress and it has been suggested that alterations in sexual behavior during stress is concomitant with spermatogenesis dysfunction.
Toktam Hajjar   +2 more
doaj   +1 more source

The effect of immobilization stress on the HPG axis (hypothalamic - pituitary - gonad) hormones and the number of spermatogonia [PDF]

open access: yesJournal of Advanced Biomedical Sciences, 2013
Background & Objective: Stress has different effects on the living organisms. In this study the effect of immobilization stress the HPG (hypothalamic - pituitary - gonad axis) hormones secretion and the number of spermatogonia was studied in adult male ...
ahmad mozafar   +5 more
doaj   +2 more sources

PC6 electroacupuncture reduces stress-induced autonomic and neuroendocrine responses in rats

open access: yesHeliyon, 2023
Stress can trigger cardiovascular disease. Both imbalance of autonomic nervous activity and increase of neurohormonal output are core aspects of stress responses and can lead to cardiovascular disease.
Zhen Ye   +7 more
doaj   +1 more source

Ranitidine reversed the hyperaemic response in the stomach of rats exposed to immobilization stress [PDF]

open access: yesالمجلة العراقية للصيدلة, 2005
The immobilization stress has been recently recognized to produce marked increase of gastric acid secretion and cause hyperaemia in the stomach . Since ranitidine reduced corpus mucosal blood flow in the stomach to basal levels, it may cause ...
M.K. Shindala, S.M. A. AL-Nuimi
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Сondition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress.

open access: yesJournal of Education, Health and Sport, 2023
We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde ) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs  under the conditions of immobilization ...
Mariana Baida   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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