Results 51 to 60 of about 2,811,674 (298)

Immobilization stress elevates IP3 receptor mRNA in adult rat hearts in a glucocorticoid-dependent manner [PDF]

open access: yes, 2002
Gene expression of the type 1 and 2 inositol 1,4,5-trisphosphate (IP3) receptors in the rat cardiac atria and ventricles and their possible modulation by single immobilization stress was studied.
Filipenko, Maxim   +11 more
core   +1 more source

Сondition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress.

open access: yesJournal of Education, Health and Sport, 2023
We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde ) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs  under the conditions of immobilization ...
Mariana Baida   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Electric foot-shock stress drives TNF-alpha production in the liver of IL-6-deficient mice [PDF]

open access: yes, 2004
Objectives: Accumulating evidence has shown that interleukin-6 (IL-6) has pleiotropic effects on a variety of biological functions, including its antiapoptotic potential during liver injury.
Chida, Y, Motomura, Y, Kubo, C, Sudo, N
core  

The Effect of Hydroalcoholic Extract of Perovskia Abrotanoides on Neuronal Density of Rats under Chronic Immobility Stress

open access: yesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: The number of neurons in the hippocampus can have a direct effect on its function. The plant Brazembel from the mint family may have antioxidant properties.
Maryam Tehranipour   +2 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Covalent Immobilization of Microbial Cells on Microchannel Surfaces

open access: yes, 2020
Microfluidic devices with integrated biological material have found many applications in analytics (e.g., protein and DNA analysis), biochemistry (e.g., PCR), and medical diagnostics (e.g., ELISA test).
Žnidaršič-Plazl, Polona,   +3 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

The Anti-Stress Effect of Mentha arvensis in Immobilized Rats [PDF]

open access: yesInternational Journal of Molecular Sciences, 2018
Stress can lead to inflammation, accelerated aging, and some chronic diseases condition. Mentha arvensis (MA) is a traditional medicine having antioxidant and anti-inflammatory activities. The present study investigated the anti-stress role of MA and fermented MA (FMA) extract in immobilized rats.
Tian, Weishun   +9 more
openaire   +2 more sources

Comparison of Effects of Three Distinct Stress Models on Anxiety and/or Depression-Related Behaviors in Female Rats

open access: yesSakarya Tıp Dergisi, 2019
Objective: The aim of the present study was to compare the effects of three distinct stress protocols on anxiety/depression-related behaviors in adult female rats.Material and Methods: Adult Wistar rats were randomly divided into four groups (n=8) as ...
Zafer Şahin   +7 more
doaj  

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