Results 61 to 70 of about 2,811,674 (298)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Galectin-3 Decreases in Mice Exposed to Immobilization Stress

Stress, 2000
Using M3/38 monoclonal antibody we have analyzed effects of immobilization stress on the expression of galectin-3 in liver, spleen and peritoneal macrophages from adult RFM and C3H mice, as well as from aged C3H mice (total of 22 animals). In all analyzed tissues, immobilization stress caused a significant decrease in the expression of galectin-3 ...
Dumić, Jerka, Barišić, Karmela, Flögel, Mirna, Lauc, Gordan   +3 more
openaire   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Immobilization of invertase in conducting copolymers of 3-methylthienyl methacrylate

, 2003
Immobilization of invertase in conducting copolymer matrices of 3-methylthienyl methacrylate with pyrrole and thiophene was achieved by constant potential electrolysis using sodium dodecyl sulfate (SDS) as the supporting electrolyte.
Yagci, Y., Cirpan, ALİ, Çırpan, Ali, YAGCI, Y, ALKAN, S, Hepuzer, Y., Alkan, S., Toppare, Levent Kamil, HEPUZER, Y   +8 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Bifidobacterium longum P77 and Lactiplantibacillus plantarum P72 and Their Mix—Live or Heat-Treated—Mitigate Sleeplessness and Depression in Mice: Involvement of Serotonergic and GABAergic Systems

Cells
Sleeplessness (insomnia) is a significant symptom associated with stress-induced depression/anxiety. In the present study, we selected Bifidobacterium longum P77, which increased serotonin production in corticosterone-stimulated SH-SY5Y cells, from the ...
Ji-Su Baek, Xiaoyang Ma, Hee-Seo Park, Dong-Yun Lee, Dong-Hyun Kim   +4 more
doaj   +1 more source

The effect of immobilization stress on the pharmacokinetics of omeprazole in rats. [PDF]

, 2002
The effects of immobilization stress on the pharmacokinetics of omeprazole were studied in rats. The immobilization stress for 30 or 60 min immediately after oral administration of the drug caused an increase in the time to reach the maximum ...
Araki, Hiroaki, Hashimoto, Yasuhiko, Watanabe, Kazuhide, Matsuka, Naoyuki, Okazaki, Masatoshi, Gomita, Yutaka   +5 more
core   +1 more source

EFFECTS OF VITAMINSC AND E ON STRESS-INDUCED LIPID PEROXIDATION AND ANTIOXIDANT-ENZYME ACTIVITIES IN RATS

Zagazig Journal of Pharmaceutical Sciences, 2000
Immobilization stress induces the formation of reactive oxygen species and leads to the oxidative stress injury in various tissues. The present study was carried out in order to assess the effect of immobilization stress on the level of lipid peroxides ...
Randa Mostafa , Sahar Kamal , Yasser Moustafa , El-Sayed El-Awady   +3 more
doaj   +1 more source

Vasopressin modulates hypothalamo-pituitary activity by paracrine action during acute and chronic immobilization stress in rats [PDF]

Archives of Biological Sciences, 2011
The aim of the study was to examine changes in corticotropin releasing hormone (CRH), vasopressin (VP), adrenocorticotropin (ACTH) as well as VP3 receptor protein concentration in the hypothalamus and the pituitary of rats exposed to acute (3 h) and ...
Lakić Iva, Vujović P., Jasnić N., Đurašević S., Cvijić Gordana   +4 more
doaj   +1 more source