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Immune-mediated necrotizing myopathy: antibodies and forecast. A literature review
Anales de Pediatría (English Edition)Blanca Toledo del Castillo +3 more
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Immune-mediated necrotizing myopathy (IMNM): A myopathological challenge
Autoimmunity Reviews, 2022This review is focused on the myopathological spectrum of immune mediated necrotizing myopathies (IMNMs) and its differentiation with other, potentially mimicking, inflammatory and non-inflammatory myopathies. IMNMs are a subgroup of idiopathic inflammatory myopathies (IIMs) characterized by severe clinical presentation with rapidly progressive ...
Merlonghi G., Antonini G., Garibaldi M.
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[Immune-Mediated Necrotizing Myopathy(IMNM)].
Brain and nerve = Shinkei kenkyu no shinpo, 2021Immune-mediated necrotizing myopathy (IMNM) has recently been classified from polymyositis, and it clinically shows subacute progressive proximal dominant muscle weakness. Laboratory examinations show a great increase in serum creatine kinase and prominent necrotic muscle fibers without any pathological invasion of inflammatory cells.
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Immune-mediated necrotizing myopathy
Zeitschrift für Rheumatologie, 2016Immune-mediated necrotizing myopathy (IMNM) is a newly identified subgroup of idiopathic inflammatory myopathies. It is defined as a rare and severe disease, with symmetrical and proximal muscle weakness and a characteristic histology. An autoimmune aspect of IMNM is suggested by its association with autoantibodies directed against signal recognition ...
Werner Stenzel +6 more
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Immune-mediated necrotizing myopathy: clinical features and pathogenesis
Nature Reviews Rheumatology, 2020Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA reductase (anti-HMGCR) myositis-specific autoantibodies, although ~20% of patients with IMNM remain ...
Allenbach, Yves +3 more
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Immune-Mediated Necrotizing Myopathy (IMNM) [PDF]
, 2019 Immune-mediated necrotizing myopathy (IMNM) is a distinct subset of the idiopathic inflammatory myopathies, characterized by proximal muscle weakness and muscle atrophy, markedly elevated CK levels, and myocyte necrosis with minimal inflammatory infiltrate on muscle biopsy.
Brittany L. Adler +1 more
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Immune‐mediated necrotizing myopathy associated with statins
Muscle & Nerve, 2009AbstractWe report patients from two neuromuscular centers who were evaluated between the years 2000 and 2008 and met the following criteria: (1) proximal muscle weakness occurring during or after treatment with statins; (2) elevated serum creatine kinase (CK); (3) persistence of weakness and elevated CK despite discontinuation of the statin; (4 ...
Phyllis Grable-Esposito +6 more
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Spectrum of immune-mediated necrotizing myopathies and their treatments
Current Opinion in Rheumatology, 2016Purpose of reviewThis review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs).Recent findingsAutoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define two unique subtypes of necrotizing ...
Andrew L. Mammen, Iago Pinal-Fernandez
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