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Spectrum of immune-mediated necrotizing myopathies and their treatments
Current Opinion in Rheumatology, 2016Purpose of reviewThis review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs).Recent findingsAutoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define two unique subtypes of necrotizing ...
Andrew L. Mammen, Iago Pinal-Fernandez
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Management of immune‐mediated necrotizing myopathy
Muscle & NerveAbstractThe immune‐mediated necrotizing myopathies (IMNM) are autoimmune myositides clinically characterized by proximal predominant weakness and elevated creatine kinase (CK). They may be associated with autoantibodies (anti‐HMGCR, anti‐SRP), triggered by statin use (e.g., anti‐HMGCR myopathy), associated with cancer, or may be idiopathic ...
Joome, Suh, Anthony A, Amato
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HLA-DRB1 alleles in immune-mediated necrotizing myopathy
Neurology, 2016Immune-mediated necrotizing myopathy (IMNM), also known as necrotizing autoimmune myopathy, is a histologic entity characterized by marked necrosis in the absence of prominent lymphocytes.1 Risk factors or triggers for IMNM include statin treatment, cancer, and connective tissue disease (CTD).1,2 Although autoantibodies against signal recognition ...
Norihiro Suzuki +11 more
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Immune-Mediated Necrotizing Myopathy: Update on Diagnosis and Management
Current Rheumatology Reports, 2015The idiopathic inflammatory myopathies (IIMs) comprise a group of autoimmune disorders that target skeletal muscle. They are characterized by typical laboratory and clinical features including muscle weakness, elevated muscle enzymes, characteristic histopathology of muscle biopsies, as well as electromyography abnormalities.
Pari Basharat, Lisa Christopher-Stine
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Immune-Mediated Necrotizing Myopathies: Current Landscape
Current Neurology and Neuroscience ReportsImmune-mediated necrotizing myopathy (IMNM), characterized by acute or subacute onset, severe weakness, and elevated creatine kinase levels, poses diagnostic and therapeutic challenges. This article provides a succinct overview of IMNM, including clinical features, diagnostic strategies, and treatment approaches.Recent insights highlight the different ...
Christoforos, Koumas +1 more
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Immune‐mediated necrotizing myopathy: Unusual presentations of a treatable disease
Muscle & Nerve, 2021AbstractIntroduction/AimsImmune‐mediated necrotizing myopathy (IMNM) is an immune‐mediated myopathy typically presenting with progressive subacute weakness and characteristic, but nonspecific, myopathological findings. Atypical cases however can mimic other inherited or acquired myopathies, depriving patients of treatment.
Stefan Nicolau +5 more
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Association of immune‐mediated necrotizing myopathy with
Immune‐mediated necrotizing myopathy (IMNM) is a type of autoimmune myositis typically characterized clinically by proximal muscle weakness with elevated creatine kinase levels, pathologically by myofiber necrosis and regeneration with paucity of lymphocytic cell infiltration, and serologically by the presence of either of two myositis‐specific ...
Yuko Ohnuki +7 more
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Granulomatous myopathy co-existent immune-mediated necrotizing myopathy: A case report
Clinical Neurology and Neurosurgery, 2023Granulomatous myopathy (GM) is a rare disease characterized by non-caseating inflammation of the skeletal muscle, with sarcoidosis as a common cause. Here, we report a case of GM co-existent immune-mediated necrotizing myopathy (IMNM) in which an anti-signal recognition particle (SRP) antibody was positive and a muscle biopsy showed a non-caseating ...
Chunli, Yin +4 more
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Statins and immune-mediated necrotizing myopathy: Variability in the risk
TherapiesImmune-mediated necrotizing myopathy (IMNM) is a form of statin myopathy characterized by the presence of antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti HMGCR).The aim of this study was to investigate the relationship between the different statins and the risk of IMNM.A two-time approach was used.
Thierry Trenque +5 more
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Journal of Clinical Neuromuscular Disease, 2008
ABSTRACT Objective: To describe the clinical course and steroid responsiveness of a patient with subacute proximal symmetric weakness, very high serum creatine kinase activity, and myopathic pattern with fibrillations in the electromyogram, whose muscle biopsy showed necrotizing myopathy, with practically no ...
Ron Dabby, Menachem Sadeh
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ABSTRACT Objective: To describe the clinical course and steroid responsiveness of a patient with subacute proximal symmetric weakness, very high serum creatine kinase activity, and myopathic pattern with fibrillations in the electromyogram, whose muscle biopsy showed necrotizing myopathy, with practically no ...
Ron Dabby, Menachem Sadeh
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