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Immune-Mediated Necrotizing Myopathy
Brain and nerve = Shinkei kenkyu no shinpoImmune-mediated necrotizing myopathy (IMNM) is a form of autoimmune myositis characterized by the presence of necrotic and regenerating process as a major finding in the muscle. Anti-SRP and anti-HMGCR have been identified as IMNM-specific autoantibodies.
Wafa Elgeadi Saleh +1 more
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Granulomatous myopathy co-existent immune-mediated necrotizing myopathy: A case report
Clinical Neurology and Neurosurgery, 2023Granulomatous myopathy (GM) is a rare disease characterized by non-caseating inflammation of the skeletal muscle, with sarcoidosis as a common cause. Here, we report a case of GM co-existent immune-mediated necrotizing myopathy (IMNM) in which an anti-signal recognition particle (SRP) antibody was positive and a muscle biopsy showed a non-caseating ...
Chunli, Yin +4 more
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Immune‐mediated necrotizing myopathy associated with statins
Muscle & Nerve, 2009Abstract We report patients from two neuromuscular centers who were evaluated between the years 2000 and 2008 and met the following criteria: (1) proximal muscle weakness occurring during or after treatment with statins; (2) elevated serum creatine kinase (CK); (3) persistence of weakness and elevated CK despite discontinuation of the
Phyllis, Grable-Esposito +5 more
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HLA-DRB1 alleles in immune-mediated necrotizing myopathy
Neurology, 2016Immune-mediated necrotizing myopathy (IMNM), also known as necrotizing autoimmune myopathy, is a histologic entity characterized by marked necrosis in the absence of prominent lymphocytes.1 Risk factors or triggers for IMNM include statin treatment, cancer, and connective tissue disease (CTD).1,2 Although autoantibodies against signal recognition ...
Yuko, Ohnuki +11 more
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[Immune-Mediated Necrotizing Myopathy(IMNM)].
Brain and nerve = Shinkei kenkyu no shinpo, 2021Immune-mediated necrotizing myopathy (IMNM) has recently been classified from polymyositis, and it clinically shows subacute progressive proximal dominant muscle weakness. Laboratory examinations show a great increase in serum creatine kinase and prominent necrotic muscle fibers without any pathological invasion of inflammatory cells.
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Immune-Mediated Necrotizing Myopathies: Current Landscape
Current Neurology and Neuroscience ReportsImmune-mediated necrotizing myopathy (IMNM), characterized by acute or subacute onset, severe weakness, and elevated creatine kinase levels, poses diagnostic and therapeutic challenges. This article provides a succinct overview of IMNM, including clinical features, diagnostic strategies, and treatment approaches.Recent insights highlight the different ...
Christoforos, Koumas +1 more
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Management of immune‐mediated necrotizing myopathy
Muscle & NerveAbstractThe immune‐mediated necrotizing myopathies (IMNM) are autoimmune myositides clinically characterized by proximal predominant weakness and elevated creatine kinase (CK). They may be associated with autoantibodies (anti‐HMGCR, anti‐SRP), triggered by statin use (e.g., anti‐HMGCR myopathy), associated with cancer, or may be idiopathic ...
Joome, Suh, Anthony A, Amato
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Journal of Clinical Neuromuscular Disease, 2008
ABSTRACT Objective: To describe the clinical course and steroid responsiveness of a patient with subacute proximal symmetric weakness, very high serum creatine kinase activity, and myopathic pattern with fibrillations in the electromyogram, whose muscle biopsy showed necrotizing myopathy, with practically no ...
Menachem, Sadeh, Ron, Dabby
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ABSTRACT Objective: To describe the clinical course and steroid responsiveness of a patient with subacute proximal symmetric weakness, very high serum creatine kinase activity, and myopathic pattern with fibrillations in the electromyogram, whose muscle biopsy showed necrotizing myopathy, with practically no ...
Menachem, Sadeh, Ron, Dabby
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Immune-Mediated Necrotizing Myopathy (IMNM)
2019Immune-mediated necrotizing myopathy (IMNM) is a distinct subset of the idiopathic inflammatory myopathies, characterized by proximal muscle weakness and muscle atrophy, markedly elevated CK levels, and myocyte necrosis with minimal inflammatory infiltrate on muscle biopsy.
Brittany Adler, Lisa Christopher-Stine
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Spectrum of immune-mediated necrotizing myopathies and their treatments
Current Opinion in Rheumatology, 2016Purpose of reviewThis review aims to describe the spectrum of clinical, histological, and serological features in patients with immune-mediated necrotizing myopathies (IMNMs).Recent findingsAutoantibodies recognizing the signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) define two unique subtypes of necrotizing ...
Iago, Pinal-Fernandez, Andrew L, Mammen
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