Results 41 to 50 of about 12,890,416 (254)

Promising probiotics for the treatment of nephrotoxicity induced during immune-checkpoint therapy against cancers

, 2022
The immune-related adverse events resulting from the therapy of immune checkpoint inhibitors could cause kidney injury. Inflammatory reprogramming of regulatory T helper (Treg) cells or type 17 T helper (Th17) cells might be involved in the pathogenesis ...
Sawamura Haruka, 1000050242110, Yoshikawa Sayuri, Ikeda Yuka, Matsuda Satoru, まつだ さとる, Taniguchi Kurumi, Tsuji Ai, 松田 覚   +8 more
core   +1 more source

Safety of Neoadjuvant Immunotherapy in Resectable Cancers: A Meta-Analysis

Frontiers in Immunology, 2022
BackgroundNeoadjuvant immunotherapy has preliminarily been effective in multiple resectable cancers. However, its safety is still largely unknown.MethodsA systematic literature search was conducted in PubMed, Embase, Web of Science, and Cochrane Library ...
Jiawei Xu, Yongfeng Wu, Yuedan Xu, Yuan Qiu, Xiaobo Li, Yumeng Song, Ling Zhang   +6 more
doaj   +1 more source

Temporary Severe Neutropenia during Administration of Atezolizumab: A Novel Case Report

Case Reports in Oncology, 2023
Here, we describe a case of temporary severe neutropenia after atezolizumab monotherapy and its treatment course. Atezolizumab monotherapy was introduced as a 6th-line treatment for a man in his late 60s, who was diagnosed with stage Ⅳ lung ...
Ryota Kanno, Yoshitaka Saito, Yoh Takekuma, Hajime Asahina, Mitsuru Sugawara   +4 more
doaj   +1 more source

Recent Advance in Biomarkers for Predicting Immune-related Adverse Events Caused by Immune Checkpoint Inhibitors

Zhongliu Fangzhi Yanjiu, 2021
In recent years, tumor immunotherapy with immune checkpoint as the target has attracted much attention because of its remarkable efficacy. However, with the application of immune-checkpoint inhibitors (ICIs), more and more immune-related adverse events ...
LI Ying, YIN Haoyuan, PAN Li, FENG Lei
doaj   +1 more source

Association between complaints and immune-related adverse events.

, 2022
Association between complaints and immune-related adverse events.
Yuji Miyoshi (3172629), Shohei Iwata (13883584), Junko Nishiguchi (13883590), Masato Kano (13883581), Takeshi Azuma (153452), Sachi Honda (13883587)   +5 more
core   +1 more source

Immune-related adverse events after commencing pembrolizumab therapy.

, 2019
Immune-related adverse events after commencing pembrolizumab therapy.
Hiroyuki Kurebe (5693162), Yasushi Fukuda (7109687), Junji Uchida (488633), Motohiro Tamiya (493150), Takeshi Makio (7109690), Yoshihiko Taniguchi (4875898), Ryuya Edahiro (5693165), Hidekazu Suzuki (105870), Daichi Fujimoto (3400052), Katsuya Hirano (7109684), Mitsunori Morita (4625401), Masahide Mori (5693195), Masaki Kanazu (5693186), Toshihide Yokoyama (4625404)   +13 more
core   +1 more source

Laboratory adverse events and discontinuation of therapy according to CD4+ cell count at the start of antiretroviral therapy. [PDF]

, 2014
Few data describe antiretroviral treatment (ART)-related adverse events when treatment is initiated at CD4 cell counts more than 350 cells/μl.
Chadwick, D, Gompels, Mark, Leen, Clifford, Fisher, Martin, Walsh, J, Hill, T, Hill, Teresa, Chadwick, David, Jose, Sophie, Fidler, S, Sabin, Caroline, UK CHIC Steering Committee, Walsh, John, Nelson, M, Sabin, C, Hay, Phillip, Johnson, M, Fidler, Sarah, Post, Frank, Gilson, Richard, Fisher, M, ?, ?, Jose, S, Johnson, Margaret, Quinn, Killian, Post, F, Gilson, R, Quinn, K, Hay, P, Leen, C, Gompels, M, Nelson, Mark   +31 more
core   +1 more source

Immune-Related Adverse Events of the Gastrointestinal System

, 2023
Immune checkpoint inhibitors (ICI) are a form of immunotherapy that have revolutionized the treatment of a number of cancers. Specifically, they are antibodies targeted against established and emerging immune checkpoints, such as cytotoxic T-cell antigen
Steven Nicolaides, Alex Boussioutas
core   +1 more source

Clinical and biological correlates of immune-related adverse events

, 2021
Introduction: Immune checkpoint inhibitors (ICI) have revolutionised modern cancer treatment. However, they may cause toxicities known as immune-related adverse events (irAE), which are unpredictable and potentially severe.
Li, Quan-Zhen, Park, Jason Y, Khan, Shaheen, Burke, Michael C, Gloria-McCutchen, Yvonne, von Itzstein, Mitchell S, Xie, Yang, Dowell, Jonathan E, Fattah, Farjana, Mu-Mosley, Hong, Ostmeyer, Jared, Homsi, Jade, Saltarski, Jessica M, Sheffield, Thomas, Hsiehchen, David, et al.   +15 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source