Results 151 to 160 of about 6,100,412 (305)

DKK1+ tumor cells inhibited the infiltration of CCL19+ fibroblasts and plasma cells contributing to worse immunotherapy response in hepatocellular carcinoma

Cell Death and Disease
Intra-tumor immune infiltration plays a pivotal role in the interaction with tumor cells in hepatocellular carcinoma (HCC). However, its phenotype and related spatial structure remained elusive.
Guangyu Fan, Ruyun Gao, Tongji Xie, Lin Li, Le Tang, Xiaohong Han, Yuankai Shi   +6 more
doaj   +1 more source

SLC43A2-mediated immune cell infiltration: a potential therapeutic target in acute myeloid leukemia

Frontiers in Immunology
BackgroundTumor cells compete with T cells for methionine by overexpressing SLC43A2 (solute carrier family 43 member 2), leading to T cell exhaustion. However, the correlation between SLC43A2 and immune infiltration or malignant features in acute myeloid
Mengnan Li, Tao Zhang, Bing Wang, Jile Liu, Mohan Zhao, Yanyu Jiang, Yu Zhang, Mingfeng Zhao   +7 more
doaj   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

The effect of neoadjuvant radiotherapy on immune cell infiltrates in myxofibrosarcoma

Immuno-Oncology and Technology
BACKGROUND: Myxofibrosarcoma (MFS) is a subtype of soft-tissue sarcoma for which local treatment includes neoadjuvant radiotherapy (nRT) followed by surgery. The impact of nRT on the MFS tumor immune microenvironment remains unexplored. MATERIALS AND METHODS: Paired pre-nRT biopsy and post-nRT surgery samples from 31 MFS patients were retrospectively ...
Nederkoorn, M.J.L., Flucke, U.E., Hillebrandt-Roeffen, M.H.S., Gorris, M.A.J., van Ravensteijn, S.G., van Ravensteijn, S.G., Verrijp, K., Braam, P.M., Bonenkamp, J.J., Dierselhuis, E.F., Ruijter, E., Wetzels-van der Velden, C., Kusters-vandevelde, H.V., Huysentruyt, C.J., Grefte, J.M.M., de Wilt, J.H.W., Desar, I.M.E., Versleijen-Jonkers, Y.M.H.   +17 more
openaire   +3 more sources

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Metastasis gets a little help from immune cell mitochondria

Although a role for mitochondrial transfer has been implicated in metastasis, the mechanisms are unclear. Using mouse metastatic models, Okwan-Duodu and colleagues1 report that mitochondrial transfer from non-cancer immune cells to cancer cells in the ...
Zobalova, R, Neuzil, J, Berridge, MV
core   +1 more source

Advances in Solution‐Processed Textile Triboelectric Nanogenerators: Ink Formation, Processing Strategies, Applications, and Challenges

Advanced Functional Materials, EarlyView.
Advanced ink systems for solution‐processed textile triboelectric nanogenerators are systematically summarized, spanning conductive, tribo‐negative, and tribo‐positive layers. By connecting ink chemistry, deposition methods, and device function, the present review reveals the key governing principles of solution development and highlights practical ...
Xinlong Sun, Stephen Beeby
wiley   +1 more source

Landscape of infiltrated immune cell characterization in COVID-19

Heliyon
Although the role of SARS-CoV-2-specfic immune cells has been revealed, a comprehensive understanding of immune patterns remains unknown.In this work, unsupervised consensus clustering analysis was used to classify 240 coronavirus disease 2019 (COVID-19) patients into different immune subtypes.
Wei Zheng, Yuan Zhang, Guichuan Lai, Biao Xie   +3 more
openaire   +3 more sources

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

The cancer stem cell subtype determines immune infiltration of glioblastoma

, 2012
Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells ...
Aschenbrenner, Ines, Kumar, Praveen, Beier, Christoph P., Riemenschneider, Markus J., Beier, Christoph, Schulz, Jörg B., Bogdahn, Ulrich, Spang, Rainer, Beier, Dagmar, Leukel, Petra, Weis, Joachim, Fragoulis, Athanassios, Lamszus, Katrin, Meyer, Katharina, Bruttel, Valentin, Wischhusen, Jörg, Rümmele, Petra, Hau, Peter   +17 more
core   +1 more source