Results 151 to 160 of about 6,519,090 (301)

The cancer stem cell subtype determines immune infiltration of glioblastoma

, 2012
Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells ...
Aschenbrenner, Ines, Kumar, Praveen, Beier, Christoph P., Riemenschneider, Markus J., Beier, Christoph, Schulz, Jörg B., Bogdahn, Ulrich, Spang, Rainer, Beier, Dagmar, Leukel, Petra, Weis, Joachim, Fragoulis, Athanassios, Lamszus, Katrin, Meyer, Katharina, Bruttel, Valentin, Wischhusen, Jörg, Rümmele, Petra, Hau, Peter   +17 more
core   +1 more source

DKK1+ tumor cells inhibited the infiltration of CCL19+ fibroblasts and plasma cells contributing to worse immunotherapy response in hepatocellular carcinoma

Cell Death and Disease
Intra-tumor immune infiltration plays a pivotal role in the interaction with tumor cells in hepatocellular carcinoma (HCC). However, its phenotype and related spatial structure remained elusive.
Guangyu Fan, Ruyun Gao, Tongji Xie, Lin Li, Le Tang, Xiaohong Han, Yuankai Shi   +6 more
doaj   +1 more source

Clinical Significance of Tumor Infiltrating T-Helper and Regulatory Cells in Bulgarian Cervical Cancer Patients

Biomedicines
Background and Objectives: Cervical cancer (CC), primarily caused by human papillomavirus (HPV) infection, is the most common gynecological cancer and a leading cause of cancer-related death in women.
Angel Yordanov, Polina Damyanova, Mariela Vasileva-Slaveva, Konstantina Karakadieva, Stoyan Kostov, Velizar Shivarov   +5 more
doaj   +1 more source

The effect of neoadjuvant radiotherapy on immune cell infiltrates in myxofibrosarcoma

Immuno-Oncology and Technology
BACKGROUND: Myxofibrosarcoma (MFS) is a subtype of soft-tissue sarcoma for which local treatment includes neoadjuvant radiotherapy (nRT) followed by surgery. The impact of nRT on the MFS tumor immune microenvironment remains unexplored. MATERIALS AND METHODS: Paired pre-nRT biopsy and post-nRT surgery samples from 31 MFS patients were retrospectively ...
Nederkoorn, M.J.L., Flucke, U.E., Hillebrandt-Roeffen, M.H.S., Gorris, M.A.J., van Ravensteijn, S.G., van Ravensteijn, S.G., Verrijp, K., Braam, P.M., Bonenkamp, J.J., Dierselhuis, E.F., Ruijter, E., Wetzels-van der Velden, C., Kusters-vandevelde, H.V., Huysentruyt, C.J., Grefte, J.M.M., de Wilt, J.H.W., Desar, I.M.E., Versleijen-Jonkers, Y.M.H.   +17 more
openaire   +3 more sources

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Landscape of infiltrated immune cell characterization in COVID-19

Heliyon
Although the role of SARS-CoV-2-specfic immune cells has been revealed, a comprehensive understanding of immune patterns remains unknown.In this work, unsupervised consensus clustering analysis was used to classify 240 coronavirus disease 2019 (COVID-19) patients into different immune subtypes.
Wei Zheng, Yuan Zhang, Guichuan Lai, Biao Xie   +3 more
openaire   +3 more sources

Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces

Advanced Functional Materials, EarlyView.
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng, TzuChun Chung, Katpady Akhil Tantry, Siyu Wu, Jing Tian, Yunqi Cui, Lanyu Li, Yongzan Zhou, Zhilei Zhang, Zhe Su, Gaili Cao, Kun‐Wei Yeh, Ruipeng Li, Xianghui Xiao, Adam F. G. Leontowich, Yuan‐Yu Hsueh, Zhao Pan, Kam C. Tam, Badri Narayanan, Song Li, Yimin. A. Wu   +20 more
wiley   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Immune cell infiltration in head and neck squamous cell carcinoma and patient outcome: a retrospective study

, 2018
Background: Human papillomavirus (HPV) prevalence in oropharynx squamous cell carcinoma (OPSCC) is on the rise. HPV-linked OPSCCs represent a distinct clinical entity with a better treatment response and patient survival compared to tumors not linked to ...
Caroline Bouzin, Caroline Bouzin (476288), Marbaix, Etienne, Bouzin, Caroline, Pierre Mahy (4902190), Schneider, Karolin, Marc Hamoir, Mahy, Pierre, Pierre Mahy, Vanesa Bol (361872), Vincent Grégoire, Etienne Marbaix (416186), Etienne Marbaix, Hamoir, Marc, Bol, Vanesa, Grégoire, Vincent, Karolin Schneider, Vincent Grégoire (806693), Vanesa Bol, Karolin Schneider (4902193), Marc Hamoir (4874896)   +20 more
core   +1 more source