Results 1 to 10 of about 3,195,227 (346)

The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism [PDF]

, 2019
Recent evidence suggests that PPARγ agonists may promote anti-tumor immunity. We show that immunogenic PDV cutaneous squamous cell carcinoma (CSCC) tumors are rejected when injected intradermally at a low cell number (1 × 106) into immune competent ...
Derr-Yellin, Ethel, Ermatov, Nurmukambed, Konger, Raymond L., Ren, Lu, Sahu, Ravi P.   +4 more
core   +3 more sources

Crosstalk Between Four Types of RNA Modification Writers Characterizes the Tumor Immune Microenvironment Infiltration Patterns in Skin Cutaneous Melanoma

Frontiers in Cell and Developmental Biology, 2022
The “writers” of four types of adenosine (A)-related RNA modifications (N6-methyladenosine, N1-methyladenosine, alternative polyadenylation, as well as A-to-inosine RNA editing) are closely related to the tumorigenesis and progression of many cancer ...
Shichao Zhang, Yu Xiong, Chaochao Zheng, Jinhua Long, Houming Zhou, Zhu Zeng, Yan Ouyang, Fuzhou Tang   +7 more
doaj   +1 more source

Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma

Frontiers in Cell and Developmental Biology, 2022
Messenger RNA vaccines are considered to be a promising strategy in cancer immunotherapy, while their application on mesothelioma is still largely uncharacterized. This study aimed to identify potential antigens in mesothelioma for anti-mesothelioma mRNA
Shichao Zhang, Shuqin Li, Ya Wei, Yu Xiong, Qin Liu, Zuquan Hu, Zhu Zeng, Fuzhou Tang, Yan Ouyang   +8 more
doaj   +1 more source

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Biomolecules, 2022
Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and minimize damage to normal tissues. It offers advantages including high spatiotemporal selectivity, low side effects, and maximal preservation of tissue functions ...
Liang Hong, Jiangmin Li, Yali Luo, Tao Guo, Chenshuang Zhang, Sha Ou, Yaohang Long, Zuquan Hu   +7 more
doaj   +1 more source

Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer

Nature Communications, 2022
Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen, Rajesh Menon, Lesley J. Calder, Pavel Tolar, Peter B. Rosenthal   +4 more
doaj   +1 more source

WBC Count and WBC to Hb Ratio Could Predict Short-Term Recurrence Rate in Multiple Myeloma Patients Underwent Autologous Stem Cell Transplantation

Acta Medica Iranica, 2023
Multiple myeloma (MM) is a hematologic malignancy with a variable clinical course. We investigated the prognostic role of routine laboratory factors including CBC indices and serum vitamin D levels to predict MM recurrence after receiving an autologous ...
Hengameh Mojdeganlou, Ata Abbasi, Rahim Asghari   +2 more
doaj   +1 more source

Roles of ion channels in immune cells [PDF]

, 2016
The Editorial on the Research Topic - Roles of Ion Channels in Immune ...
Amanda eMacKenzie, Leanne eStokes, Leanne eStokes, Ronald eSluyter, Ronald eSluyter, Ronald eSluyter   +5 more
core   +10 more sources

Functional status analysis of RNH1 in bladder cancer for predicting immunotherapy response

Scientific Reports, 2023
Bladder cancer (BLCA) typically has a poor prognosis due to high rates of relapse and metastasis. Although the emergence of immunotherapy brings hope for patients with BLCA, not all patients will benefit from it.
Sen Chen, Jun Ran, Zhouqian Fan, Mingyou Liu, Liang Wu, Qiude Li, Jian Peng, Zuquan Hu   +7 more
doaj   +1 more source

Molecular characterization and transcriptomic analysis of a novel polymycovirus in the fungus Talaromyces amestolkiae

Frontiers in Microbiology, 2022
Talaromyces amestolkiae is an important fungal species owing to its ubiquity in soils, plants, air, and food. In this study, we identified a novel six-segmented polymycovirus, Talaromyces amestolkiae polymycovirus 1 (TaPmV-1). Each of the double-stranded
Li Teng, Li Teng, Sen Chen, Sen Chen, Zuquan Hu, Zuquan Hu, Jili Chen, Jili Chen, Hongmei Liu, Hongmei Liu, Tingting Zhang, Tingting Zhang, Tingting Zhang   +12 more
doaj   +1 more source

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source