Results 1 to 10 of about 14,522,121 (350)

Crosstalk Between Four Types of RNA Modification Writers Characterizes the Tumor Immune Microenvironment Infiltration Patterns in Skin Cutaneous Melanoma

Frontiers in Cell and Developmental Biology, 2022
The “writers” of four types of adenosine (A)-related RNA modifications (N6-methyladenosine, N1-methyladenosine, alternative polyadenylation, as well as A-to-inosine RNA editing) are closely related to the tumorigenesis and progression of many cancer ...
Shichao Zhang, Yu Xiong, Chaochao Zheng, Jinhua Long, Houming Zhou, Zhu Zeng, Yan Ouyang, Fuzhou Tang   +7 more
doaj   +1 more source

Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma

Frontiers in Cell and Developmental Biology, 2022
Messenger RNA vaccines are considered to be a promising strategy in cancer immunotherapy, while their application on mesothelioma is still largely uncharacterized. This study aimed to identify potential antigens in mesothelioma for anti-mesothelioma mRNA
Shichao Zhang, Shuqin Li, Ya Wei, Yu Xiong, Qin Liu, Zuquan Hu, Zhu Zeng, Fuzhou Tang, Yan Ouyang   +8 more
doaj   +1 more source

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, 2021
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, J. Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu, S. Shi   +9 more
semanticscholar   +1 more source

Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health

Cells, 2023
Immune cells and commensal microbes in the human intestine constantly communicate with and react to each other in a stable environment in order to maintain healthy immune activities.
C. Mazziotta, M. Tognon, F. Martini, E. Torreggiani, J. Rotondo   +4 more
semanticscholar   +1 more source

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Biomolecules, 2022
Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and minimize damage to normal tissues. It offers advantages including high spatiotemporal selectivity, low side effects, and maximal preservation of tissue functions ...
Liang Hong, Jiangmin Li, Yali Luo, Tao Guo, Chenshuang Zhang, Sha Ou, Yaohang Long, Zuquan Hu   +7 more
doaj   +1 more source

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Journal of Hematology & Oncology, 2023
Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor microenvironment, dysregulation of amino acid consumption in immune cells is an ...
Luming Yang, Zhaole Chu, Mengmeng Liu, Qiang Zou, Jinyang Li, Qin Liu, Yazhou Wang, Tao Wang, Junyu Xiang, Bin Wang   +9 more
semanticscholar   +1 more source

Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer

Nature Communications, 2022
Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen, Rajesh Menon, Lesley J. Calder, Pavel Tolar, Peter B. Rosenthal   +4 more
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The total mass, number, and distribution of immune cells in the human body

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance We characterized the human body’s immune cells distribution and provided its total weight. Our findings show that an average individual’s immune system consists of approximately 1.8 trillion cells, weighing around 1.2 kg. Lymphocytes make up
R. Sender, Yarden Weiss, Yoav Navon, I. Milo, Nofar Azulay, Leeat Keren, Shai Fuchs, Danny Ben-Zvi, E. Noor, R. Milo   +9 more
semanticscholar   +1 more source

TIMER2.0 for analysis of tumor-infiltrating immune cells

Nucleic Acids Res., 2020
Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment.
Taiwen Li, Jingxin Fu, Zexian Zeng, David Cohen, Jing Li, Qianming Chen, Bo Li, Xiaole Shirley Liu   +7 more
semanticscholar   +1 more source

WBC Count and WBC to Hb Ratio Could Predict Short-Term Recurrence Rate in Multiple Myeloma Patients Underwent Autologous Stem Cell Transplantation

Acta Medica Iranica, 2023
Multiple myeloma (MM) is a hematologic malignancy with a variable clinical course. We investigated the prognostic role of routine laboratory factors including CBC indices and serum vitamin D levels to predict MM recurrence after receiving an autologous ...
Hengameh Mojdeganlou, Ata Abbasi, Rahim Asghari   +2 more
doaj   +1 more source