Results 41 to 50 of about 1,931,453 (167)

Hematopoietic aging: Cellular, molecular, and related mechanisms

Chinese Medical Journal
. Aging is accompanied by significant inhibition of hematopoietic and immune system function and disruption of bone marrow structure. Aging-related alterations in the inflammatory response, immunity, and stem cell niches are at the root of hematopoietic ...
Li Ye, Chuan Tian, Ye Li, Hang Pan, Jinxiu Hu, Liping Shu, Xinghua Pan, Xiangxiang Pan, Peifang Wei   +8 more
doaj   +1 more source

Novel Strategies for Peptide-Based Vaccines in Hematological Malignancies

Frontiers in Immunology, 2018
Peptides vaccination is an interesting approach to activate T-cells toward desired antigens in hematological malignancies. In addition to classical tumor associated antigens, such as cancer testis antigens, new potential targets for peptide vaccination ...
Uffe Klausen, Staffan Holmberg, Staffan Holmberg, Morten Orebo Holmström, Morten Orebo Holmström, Nicolai Grønne Dahlager Jørgensen, Jacob Handlos Grauslund, Jacob Handlos Grauslund, Inge Marie Svane, Inge Marie Svane, Mads Hald Andersen, Mads Hald Andersen   +11 more
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Immune cells and arrhythmias

Cardiovascular Research
Abstract Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide. Emerging evidence has demonstrated that resident and infiltrating cardiac immune cells play direct, mechanistic roles in arrhythmia onset and progression.
Joshua A Keefe, Jian Wang, Jiangping Song, Li Ni, Xander H T Wehrens   +4 more
openaire   +2 more sources

AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma

BMC Cancer
Background Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the
Yan Ouyang, Yan Gu, Xinhai Zhang, Ya Huang, Xianpeng Wei, Fuzhou Tang, Shichao Zhang   +6 more
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AllergoOncology: Role of immune cells and immune proteins

Clinical and Translational Allergy, 2022
AbstractBackgroundImmune cells and immune proteins play a pivotal role in host responses to pathogens, allergens and cancer. Understanding the crosstalk between allergic response and cancer, immune surveillance, immunomodulation, role of immunoglobulin E (IgE)‐mediated functions and help to develop novel therapeutic strategies.
Di Gioacchino M., Della Valle L., Allegra A., Pioggia G., Gangemi S.   +4 more
openaire   +4 more sources

The safety and feasibility of multiple intrathecal injections of allogenic NK cells in pediatrics with refractory/recurrent brain tumors

BMC Cancer
Background Pediatric glioma is a rare condition that can lead to significant mortality and morbidity due to its high recurrence rate. This study is a phase I nonrandomized clinical trial that was conducted to assess the safety, feasibility, and potential
Hamid Mahdizadeh, Amirhossein Izadpanah, Yasaman Nouri, Parisa Shams, Delbar Daneshjou, Alireza Aziz Ahari, Alireza Tabibkhooei, Hamidreza Haghighatkhah, Massoud Vosough, Pooya Faranoush, Masoumeh Azimi, Saba yousefi, Atefeh Barzegari, Alireza Khosravani, Niloufar Shayan Asl, Mohammad Faranoush, Marzieh Ebrahimi   +16 more
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Unraveling the Mystery of Breast Cancer Dormancy: Insights into Genetic, Receptor, and Cellular Interactions Driving Late Recurrence

Frontiers in Immunology
Late recurrence of breast cancer poses a considerable threat to patient survival, often attributed to breast cancer dormancy. Dormancy, characterized by cancer cells remaining quiescent for extended periods, is influenced by genetic factors and ...
Haochen Ma, Bingqiang Zhang, Mengmeng Chen, Zhendi Song, Yi Zhao   +4 more
doaj   +1 more source

Comprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry

BMC Immunology, 2022
Human peripheral blood mononuclear cells (PBMCs) originate from hematopoietic stem cells in the bone marrow, which mainly includes lymphocytes (T cells, B cells, and natural killer cells) and monocytes. Cryopreserved PBMCs providing biobank resources are
Bo Li, Chunmei Yang, Gui Jia, Yansheng Liu, Na Wang, Fangfang Yang, Rui Su, Yulong Shang, Ying Han   +8 more
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Pluripotent Stem Cells: Immune to the Immune System? [PDF]

Science Translational Medicine, 2012
Understanding the immunogenic properties of embryonic and induced pluripotent stem cells will inform the immunosuppressive requirements for successful cell therapy.
Jeremy I, Pearl, Leslie S, Kean, Mark M, Davis, Joseph C, Wu   +3 more
openaire   +2 more sources

Biodegradable and Implantable Triboelectric Nanogenerator Improved by β‐Lactoglobulin Fibrils‐Assisted Flexible PVA Porous Film

Advanced Science
Triboelectric nanogenerators (TENGs) are highly promising as implantable, degradable energy sources and self‐powered sensors. However, the degradable triboelectric materials are often limited in terms of contact electrification and mechanical properties.
Yichang Quan, Engui Wang, Han Ouyang, Lingling Xu, Lu Jiang, Lijing Teng, Jiaxuan Li, Lin Luo, Xujie Wu, Zhu Zeng, Zhou Li, Qiang Zheng   +11 more
doaj   +1 more source