Results 61 to 70 of about 2,005,391 (219)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility

Heliyon
Selenium (Se), a component of selenoproteins and selenocompounds in the human body, is crucial for the development of male reproductive organs, DNA synthesis, thyroid hormone, metabolism, and defence against infections and oxidative damage. In the testis,
Shuai Yuan, Ye Zhang, Pei-Yu Dong, Yu-Mei Chen Yan, Jing Liu, Bing-Qiang Zhang, Meng-Meng Chen, Shu-Er Zhang, Xi-Feng Zhang   +8 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The diagnostic of PAX1 gene methylation in cervical lesions and its role in the triage of non-16/18 HR-HPV positive

Frontiers in Immunology
ObjectiveThis study aims to systematically evaluate the application value of PAX1 gene methylation detection in cervical lesion screening and its potential advantages in the triage of non-16/18 high-risk human papillomavirus (HR-HPV) positive patients ...
Meng-Meng Chen, Meng-Meng Chen, Bing-Qiang Zhang, Bing-Qiang Zhang, Yan-Song Luan, Guo-Long Sun, Yun-Yuan Zhang, Xiao-Yan Zhou, Xi-Feng Zhang, Feng-Chun Gao, Jun-Mei Yu   +10 more
doaj   +1 more source

Identification of Shared Immune Cells and Immune-Related Co-Disease Genes in Chronic Heart Failure and Systemic Lupus Erythematosus Based on Transcriptome Sequencing

Journal of Inflammation Research, 2023
Ziyue Luo,1,* Guifang Lu,2,* Qiang Yang,1 Juncan Ding,1 Tianyu Wang,1 Pengfei Hu3 1Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China; 2Department of Rheumatology,
Luo Z, Lu G, Yang Q, Ding J, Wang T, Hu P   +5 more
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Pathogenicity and host-interacting mechanisms of enterogenic Enterobacter cancerogenus in silkworm

Frontiers in Microbiology
IntroductionEnterobacter cancerogenus (E. cancerogenus) is a facultative anaerobic, gram-negative bacterium that can be utilized for the biological control of pests. However, the molecular mechanisms underlying the pathogenicity of E.
Meng Luo, Linhui Lai, Zailin Wu, Zailin Wu, Zailin Wu, Xiaoli Ren, Xiaoli Ren, Xiaoli Ren, Jiacheng Zhao, Jiacheng Zhao, Jiacheng Zhao, Hongmei Liu, Hongmei Liu, Hongmei Liu, Yaohang Long, Yaohang Long, Yaohang Long   +16 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Effects of Immune Cells and Cytokines on Different Cells in OA

Journal of Inflammation Research, 2023
Pan Luo,* Qiling Yuan,* Xianjie Wan, Mingyi Yang, Peng Xu Department of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China*These authors contributed equally to this ...
Luo P, Yuan Q, Wan X, Yang M, Xu P
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