Results 1 to 10 of about 1,931,453 (167)

Crosstalk Between Four Types of RNA Modification Writers Characterizes the Tumor Immune Microenvironment Infiltration Patterns in Skin Cutaneous Melanoma

Frontiers in Cell and Developmental Biology, 2022
The “writers” of four types of adenosine (A)-related RNA modifications (N6-methyladenosine, N1-methyladenosine, alternative polyadenylation, as well as A-to-inosine RNA editing) are closely related to the tumorigenesis and progression of many cancer ...
Shichao Zhang, Yu Xiong, Chaochao Zheng, Jinhua Long, Houming Zhou, Zhu Zeng, Yan Ouyang, Fuzhou Tang   +7 more
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Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma

Frontiers in Cell and Developmental Biology, 2022
Messenger RNA vaccines are considered to be a promising strategy in cancer immunotherapy, while their application on mesothelioma is still largely uncharacterized. This study aimed to identify potential antigens in mesothelioma for anti-mesothelioma mRNA
Shichao Zhang, Shuqin Li, Ya Wei, Yu Xiong, Qin Liu, Zuquan Hu, Zhu Zeng, Fuzhou Tang, Yan Ouyang   +8 more
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Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Biomolecules, 2022
Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and minimize damage to normal tissues. It offers advantages including high spatiotemporal selectivity, low side effects, and maximal preservation of tissue functions ...
Liang Hong, Jiangmin Li, Yali Luo, Tao Guo, Chenshuang Zhang, Sha Ou, Yaohang Long, Zuquan Hu   +7 more
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Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer

Nature Communications, 2022
Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen, Rajesh Menon, Lesley J. Calder, Pavel Tolar, Peter B. Rosenthal   +4 more
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WBC Count and WBC to Hb Ratio Could Predict Short-Term Recurrence Rate in Multiple Myeloma Patients Underwent Autologous Stem Cell Transplantation

Acta Medica Iranica, 2023
Multiple myeloma (MM) is a hematologic malignancy with a variable clinical course. We investigated the prognostic role of routine laboratory factors including CBC indices and serum vitamin D levels to predict MM recurrence after receiving an autologous ...
Hengameh Mojdeganlou, Ata Abbasi, Rahim Asghari   +2 more
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Functional status analysis of RNH1 in bladder cancer for predicting immunotherapy response

Scientific Reports, 2023
Bladder cancer (BLCA) typically has a poor prognosis due to high rates of relapse and metastasis. Although the emergence of immunotherapy brings hope for patients with BLCA, not all patients will benefit from it.
Sen Chen, Jun Ran, Zhouqian Fan, Mingyou Liu, Liang Wu, Qiude Li, Jian Peng, Zuquan Hu   +7 more
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Molecular characterization and transcriptomic analysis of a novel polymycovirus in the fungus Talaromyces amestolkiae

Frontiers in Microbiology, 2022
Talaromyces amestolkiae is an important fungal species owing to its ubiquity in soils, plants, air, and food. In this study, we identified a novel six-segmented polymycovirus, Talaromyces amestolkiae polymycovirus 1 (TaPmV-1). Each of the double-stranded
Li Teng, Li Teng, Sen Chen, Sen Chen, Zuquan Hu, Zuquan Hu, Jili Chen, Jili Chen, Hongmei Liu, Hongmei Liu, Tingting Zhang, Tingting Zhang, Tingting Zhang   +12 more
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Combination of CTLA-4 blockade with MUC1 mRNA nanovaccine induces enhanced anti-tumor CTL activity by modulating tumor microenvironment of triple negative breast cancer

Translational Oncology, 2022
The immunosuppressive tumor microenvironment (TME) is the main reason for the failure of many immunotherapies that directly stimulate anti-tumor immune response.
Xuan Lin, Hedan Chen, Ying Xie, Xue Zhou, Yun Wang, Jing Zhou, Shiqi Long, Zuquan Hu, Shichao Zhang, Wei Qiu, Zhu Zeng, Lina Liu   +11 more
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Enhanced Hematopoietic Stem Cell Function Mediates Immune Regeneration following Sex Steroid Blockade

Stem Cell Reports, 2015
Mechanisms underlying age-related defects within lymphoid-lineages remain poorly understood. We previously reported that sex steroid ablation (SSA) induced lymphoid rejuvenation and enhanced recovery from hematopoietic stem cell (HSC) transplantation ...
Danika M. Khong, Jarrod A. Dudakov, Maree V. Hammett, Marc I. Jurblum, Sacha M.L. Khong, Gabrielle L. Goldberg, Tomoo Ueno, Lisa Spyroglou, Lauren F. Young, Marcel R.M. van den Brink, Richard L. Boyd, Ann P. Chidgey   +11 more
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Construction of a serum diagnostic signature based on m5C-related miRNAs for cancer detection

Frontiers in Endocrinology, 2023
Currently, no clinically relevant non-invasive biomarkers are available for screening of multiple cancer types. In this study, we developed a serum diagnostic signature based on 5-methylcytosine (m5C)-related miRNAs (m5C-miRNAs) for multiple-cancer ...
Fuzhou Tang, Yang Liu, Yichi Sun, Yu Xiong, Yan Gu, Jing Zhou, Yan Ouyang, Shichao Zhang   +7 more
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