Results 61 to 70 of about 14,522,121 (350)

CD38 ecto-enzyme in immune cells is induced during aging regulating NAD+ and NMN levels

Nature Metabolism, 2020
Decreased NAD+ levels have been shown to contribute to metabolic dysfunction during aging. NAD+ decline can be partially prevented by knockout of the enzyme CD38.
Claudia C S Chini, Thais R. Peclat, G. Warner, Sonu Kashyap, J. Espindola-Netto, Guilherme C. de Oliveira, Lilian S. Gomez, K. Hogan, M. Tarragó, A. Puranik, Guillermo Agorrody, Katie L. Thompson, K. Dang, S. Clarke, Bennett G. Childs, K. Kanamori, M. A. Witte, Paola Vidal, Anna L Kirkland, M. De Cecco, K. Chellappa, Melanie R. McReynolds, Connor S. R. Jankowski, T. Tchkonia, J. Kirkland, J. Sedivy, J. V. van Deursen, D. Baker, W. van Schooten, J. Rabinowitz, J. Baur, E. Chini   +31 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Antimicrobial Peptide Cec4 Eradicates the Bacteria of Clinical Carbapenem-Resistant Acinetobacter baumannii Biofilm

Frontiers in Microbiology, 2020
The drug resistance rate of Acinetobacter baumannii increases year on year, and the drugs available for the treatment of carbapenem-resistant A. baumannii (CRAB) infection are extremely limited. A.
Weiwei Liu, Weiwei Liu, Weiwei Liu, Zhaoying Wu, Zhaoying Wu, Zhaoying Wu, Chengju Mao, Chengju Mao, Guo Guo, Zhu Zeng, Zhu Zeng, Ying Fei, Shan Wan, Jian Peng, Jian Peng, Jian Peng, Jianwei Wu   +16 more
doaj   +1 more source

In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells [PDF]

, 2019
Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens
A Ashkenazi, A Cerwenka, A Hadji, A Orbach, AP Costa-Pereira, Baryshnikov AYu, C Fionda, H Cho, HA Elrod, I Viard-Leveugle, J Sträter, J Wu, JC Symes, K Yamamoto, L Boldrini, L Galligan, L Siena, M Christgen, M Mottolese, M Müller, M Todaro, M Villa-Morales, MA Park, ME Peter, N Gordon, O Micheau, PB Carvalho-Neto de, RW McGilvray, S Yang, V Almendro, WM Liu, Y Hirooka, Y Kimura   +32 more
core   +2 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]

, 2019
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong, Lal, Bachchu, Laterra, John, Lee, Richard S, Li, Jian Jian, Liu, Senquan, Lopez-Bertoni, Hernando, Ma, Ding, Wang, Shuyan, Wei, Shuang, Wilson, Mary Ann, Xia, Shuli, Ying, Mingyao, Zhan, Daqian, Zhang, Hao   +14 more
core   +2 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Integrated bioinformatics analysis reveals that CCBP2 and GPR87 are new GPCR-associated biomarkers for preeclampsia

Reproductive Biology and Endocrinology
Background Preeclampsia (PE) is a multifaceted pregnancy syndrome marked by multiple system involvement and a significant contributor to maternal mortality.
Jie Li, Meng-Meng Chen, Bingqiang Zhang, Yi Zhao   +3 more
doaj   +1 more source

FOXD3 Regulates VISTA Expression in Melanoma. [PDF]

, 2020
Immune checkpoint inhibitors have improved patient survival in melanoma, but the innate resistance of many patients necessitates the investigation of alternative immune targets.
Aplin, Andrew E., Berger, Adam C., Chervoneva,, Davies, Michael A., Erkes, Dan A., Fisher, David E., Gershenwald, Jeffrey E., Knecht, Meghan, Lo, Jennifer A., McCue, Peter A., Mollaee, Mehri, Purwin, Timothy J., Rosenbaum, Sheera R., Zhong, Zhijiu   +13 more
core   +1 more source

Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]

, 2017
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana, Cippitelli, Marco, Fionda, Cinzia, Santoni, Angela, Soriani, Alessandra, Zingoni, Alessandra   +5 more
core   +1 more source