Results 61 to 70 of about 3,195,227 (346)

Aberrant R-loop–mediated immune evasion, cellular communication, and metabolic reprogramming affect cancer progression: a single-cell analysis

Molecular Cancer
Dysregulation of R-loop homeostasis is closely related to various human diseases, including cancer. However, the causality of aberrant R-loops in tumor progression remains unclear.
Shichao Zhang, Yang Liu, Yichi Sun, Qin Liu, Yan Gu, Ya Huang, Zhu Zeng, Fuzhou Tang, Yan Ouyang   +8 more
doaj   +1 more source

The case for absolute ligand discrimination : modeling information processing and decision by immune T cells [PDF]

, 2015
Some cells have to take decision based on the quality of surroundings ligands, almost irrespective of their quantity, a problem we name "absolute discrimination". An example of absolute discrimination is recognition of not-self by immune T Cells. We show
Altan-Bonnet, Grégoire, François, Paul
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Hematopoietic aging: Cellular, molecular, and related mechanisms

Chinese Medical Journal
. Aging is accompanied by significant inhibition of hematopoietic and immune system function and disruption of bone marrow structure. Aging-related alterations in the inflammatory response, immunity, and stem cell niches are at the root of hematopoietic ...
Li Ye, Chuan Tian, Ye Li, Hang Pan, Jinxiu Hu, Liping Shu, Xinghua Pan, Xiangxiang Pan, Peifang Wei   +8 more
doaj   +1 more source

Novel Strategies for Peptide-Based Vaccines in Hematological Malignancies

Frontiers in Immunology, 2018
Peptides vaccination is an interesting approach to activate T-cells toward desired antigens in hematological malignancies. In addition to classical tumor associated antigens, such as cancer testis antigens, new potential targets for peptide vaccination ...
Uffe Klausen, Staffan Holmberg, Staffan Holmberg, Morten Orebo Holmström, Morten Orebo Holmström, Nicolai Grønne Dahlager Jørgensen, Jacob Handlos Grauslund, Jacob Handlos Grauslund, Inge Marie Svane, Inge Marie Svane, Mads Hald Andersen, Mads Hald Andersen   +11 more
doaj   +1 more source

Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation [PDF]

, 2022
Xi Liu, Péter Nagy, Alessandro Bonfini, Philip Houtz, Xiao‐Li Bing, Xiaowei Yang, Nicolas Buchon   +6 more
openalex   +1 more source

Trained Immunity Carried by Non-immune Cells [PDF]

Frontiers in Microbiology, 2019
"Trained immunity" is a term proposed by Netea to describe the ability of an organism to develop an exacerbated immunological response to protect against a second infection independent of the adaptative immunity. This immunological memory can last from 1 week to several months and is only described in innate immune cells such as monocytes, macrophages,
Hamada, Attoumani, Torre, Cedric, Drancourt, Michel, Ghigo, Eric   +3 more
openaire   +4 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

FOXD3 Regulates VISTA Expression in Melanoma. [PDF]

, 2020
Immune checkpoint inhibitors have improved patient survival in melanoma, but the innate resistance of many patients necessitates the investigation of alternative immune targets.
Aplin, Andrew E., Berger, Adam C., Chervoneva,, Davies, Michael A., Erkes, Dan A., Fisher, David E., Gershenwald, Jeffrey E., Knecht, Meghan, Lo, Jennifer A., McCue, Peter A., Mollaee, Mehri, Purwin, Timothy J., Rosenbaum, Sheera R., Zhong, Zhijiu   +13 more
core   +1 more source

High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based on public databases [PDF]

, 2022
Linrong Li, Lin Li, Qiang Sun
openalex   +1 more source