Results 71 to 80 of about 3,195,227 (346)

T cell immune abnormalities in immune thrombocytopenia [PDF]

Journal of Hematology & Oncology, 2014
Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition.
Ji, Xuebin, Zhang, Liping, Peng, Jun, Hou, Ming   +3 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma

BMC Cancer
Background Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the
Yan Ouyang, Yan Gu, Xinhai Zhang, Ya Huang, Xianpeng Wei, Fuzhou Tang, Shichao Zhang   +6 more
doaj   +1 more source

Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells [PDF]

, 2002
Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact.
Göke, B., Haberberger, R., Hagner, S., Knauer, J., McGregor, G. P., Voigt, K.   +5 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The safety and feasibility of multiple intrathecal injections of allogenic NK cells in pediatrics with refractory/recurrent brain tumors

BMC Cancer
Background Pediatric glioma is a rare condition that can lead to significant mortality and morbidity due to its high recurrence rate. This study is a phase I nonrandomized clinical trial that was conducted to assess the safety, feasibility, and potential
Hamid Mahdizadeh, Amirhossein Izadpanah, Yasaman Nouri, Parisa Shams, Delbar Daneshjou, Alireza Aziz Ahari, Alireza Tabibkhooei, Hamidreza Haghighatkhah, Massoud Vosough, Pooya Faranoush, Masoumeh Azimi, Saba yousefi, Atefeh Barzegari, Alireza Khosravani, Niloufar Shayan Asl, Mohammad Faranoush, Marzieh Ebrahimi   +16 more
doaj   +1 more source

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. [PDF]

, 2019
Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as well as by regulatory T (Treg) cells that restrict the function of effector T cells and thereby promote tumour growth1.
Cadilha, Bruno L, Carrizosa, Esteban, Di Pilato, Mauro, Kim, Edward Y, Ligorio, Matteo, Mani, Vinidhra, Marangoni, Francesco, Medoff, Benjamin D, Mempel, Thorsten R, Misale, Sandra, Nasrallah, Mazen N, Prüßmann, Jasper N, Seruggia, Davide, Usmani, Shariq M, Villani, Alexandra-Chloe, Warner, Ross D, Zappulli, Valentina   +16 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Unraveling the Mystery of Breast Cancer Dormancy: Insights into Genetic, Receptor, and Cellular Interactions Driving Late Recurrence

Frontiers in Immunology
Late recurrence of breast cancer poses a considerable threat to patient survival, often attributed to breast cancer dormancy. Dormancy, characterized by cancer cells remaining quiescent for extended periods, is influenced by genetic factors and ...
Haochen Ma, Bingqiang Zhang, Mengmeng Chen, Zhendi Song, Yi Zhao   +4 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source