Results 251 to 260 of about 126,887 (307)

Temporal dynamics in cancer immunotherapy: the interplay between circadian rhythms, tumor microenvironment, and immune checkpoint blockade. [PDF]

J Natl Cancer Cent
Lin A, Fang X, Zhang P, Zhang N, Liu Z, Cheng Q, Zhang J, Tang B, Luo P.   +8 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Targeting the tumor microenvironment in cholangiocarcinoma to improve immune checkpoint blockade: potential strategies and translational pre-clinical models. [PDF]

Clin Transl Immunology
Jessel MD, McGreevy O, McReynolds L, Dahal LN, Gilbert T, Malik HZ, Goldring CE, Randle LE.   +7 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Modulation of fibronectin extracellular matrix enhances anti-tumor efficacy of immune checkpoint blockade. [PDF]

Cell Rep Med
Khan KA, Caunt Mitzner M, Cruz-Munoz W, Li G, Himmels P, Xu P, Kuo HY, Jesudason R, Gogineni A, Weimer R, Chow A, Piskol R, Michael IP, Ye W, Kerbel RS.   +14 more
europepmc   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

PPP2R2A insufficiency enhances PD-L1 immune checkpoint blockade efficacy in lung cancer through cGAS-STING activation. [PDF]

J Clin Invest
Qiu Z, Song NJ, Li A, Singh D, Prasad CB, Yan C, Carbone DP, Wang QE, Zhang X, Li Z, Zhang J.   +10 more
europepmc   +1 more source

Immune-related adverse events occurring rapidly after a single dose of immune checkpoint blockade. [PDF]

J Immunother Cancer
Guitton R, Laparra A, Chanson N, Champiat S, Danlos FX, Michot JM, Messayke S, Marabelle A, Lambotte O.   +8 more
europepmc   +1 more source

Recent advances in nanoparticles-based sonodynamic and immune checkpoint blockade synergistic therapy for pancreatic ductal adenocarcinoma. [PDF]

Mater Today Bio
Li H, Lei Y, Tian Y, Nie H, Li Y, Mi Y.
europepmc   +1 more source

Sequential Tumor Microenvironment Reprogramming by Nanoplatform Potentiates Sonodynamic-Chemodynamic Therapy and Immune Checkpoint Blockade in Breast Cancer. [PDF]

Adv Sci (Weinh)
Yu Y, Song Z, Zhu A, Li J, Fan R, Xiao B.   +5 more
europepmc   +1 more source