Results 81 to 90 of about 1,265,615 (248)

Immune checkpoint blockade in experimental bacterial infections

Immune checkpoint inhibitors designed to reinvigorate immune responses suppressed by cancer cells have revolutionized cancer therapy. Similarities in immune dysregulation between cancer and infectious diseases has prompted investigations into the role of
Jensen, Peter Ø., Jensen, Louise K., Henriksen, Nicole L   +2 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Checkpoint Blockade in Cancer Immunotherapy: Squaring the Circle [PDF]

, 2015
Manipulating the complex interaction between the immune system and tumour cells has been the focus of cancer research for many years, but it is only in the past decade that significant progress has been made in the field of cancer immunotherapy resulting
Maria A.V. Marzolini, Karl S. Peggs, Sergio A. Quezada   +2 more
core  

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

A landscape of checkpoint blockade resistance in cancer: underlying mechanisms and current strategies to overcome resistance

Cancer Biology & Therapy
The discovery of immune checkpoints and the development of immune checkpoint inhibitors (ICI) have achieved a durable response in advanced-stage cancer patients.
Ginette S. Santiago-Sánchez, Kellsye P. Fabian, James W. Hodge   +2 more
doaj   +1 more source

Turning Cancer Immunotherapy to the Emerging Immune Checkpoint TIGIT: Will This Break Through the Limitations of the Legacy Approach? [PDF]

The discovery of immune checkpoints (ICs) has pushed cancer treatment into the next era. As an emerging immune checkpoint, the TIGIT/CD155 axis inhibits the cytotoxicity of T and NK cells through multiple pathways.
Elkord, Eyad, Tripp, Ralph A, Cui, Haozhe   +2 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Immunogenomics of colorectal cancer response to immune checkpoint blockade: Imaging Mass Cytometry

, 2020
Immunogenomics of colorectal cancer response to immune checkpoint blockade Imaging Mass Cytometry data supporting the paper: "Immunogenomics of colorectal cancer response to immune checkpoint blockade" The provided data includes: Sample metadata ...
Katrina, Todd, Shiu, Kai-Keen, Wilson, Gareth A., Montorsi, Lucia, Temelkovski, Damjan, Rodriguez-Justo, Manuel, Spencer, Jo, Nedyalko, Petrov, John, Susan, Bortolomeazzi, Michele, Swanton, Charles, Keddar, Mohamed Reda, Al Bakir, Maise, Benedetti, Lorena, Parker, Peter, Ward, Sophia, Miles, James, Larijani, Banafshe, Choi, Subin, Ciccarelli, Francesca D.   +19 more
core   +1 more source

Nature Communications / B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma [PDF]

, 2019
Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses.
Simon, Martin, Glatz, Katharina, Hartl, Markus, Steinberger, Peter, Bock, Christoph, Roka, Florian, Mertz, Kirsten D., Somasundaram, Rajasekharan, Zhang, Gao, Wagner, Stephan N., Wiesner, Thomas, Chen, Minyi, Grabmeier-Pfistershammer, Katharina, Wagner, Christine, Maurer-Granofszky, Margarita, Läubli, Heinz, Grabmeier-Pstershammer, Katharina, Penz, Thomas, Griss, Johannes Maximilian, Bauer, Wolfgang, Petzelbauer, Peter, Pickl, Winfried F., Griss, Johannes, Herlyn, Meenhard   +23 more
core   +1 more source

DNA repair and immune checkpoint blockade response

, 2022
•Mutations in seven DNA repair genes (ATM, ATR, POLE, ERCC4, NBN, RAD50, PARP1) were significantly associated with improved overall survival (OS) in patients treated with immune checkpoint blockade (ICB) (p 10%) with NER and/or DNAsense mutations.•We ...
Jennifer Su, Shiau, Carina, Brandon A. Mahal, William L. Hwang, Hoffman, Hannah I., Hwang, William L., Alshalalfa, Mohammed, Carina Shiau, Kim, Daniel Y., Su, Jennifer, Hannah I. Hoffman, Mahal, Brandon A., Guo, Jimmy A., Daniel Y. Kim, Jimmy A. Guo, Mohammed Alshalalfa   +15 more
core   +1 more source