Results 241 to 250 of about 15,424 (278)

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Efficacy of current therapeutic strategies for immune checkpoint inhibitor-related esophagitis. [PDF]

Ann Gastroenterol
Cruz CC, Santos MJMN, Wali S, Mortan R, Ahuja R, Rong J, Gupta T, Lee IJ, Natha C, Vemulapalli V, Ngo S, Takigawa K, Varatharajalu K, Kennedy LB, Pabani A, Schneider BP, Kim KC, Shafi MA, Thomas AS, Wang Y.   +19 more
europepmc   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

Neuro-immune crosstalk in breast cancer: molecular mechanisms from stress signals to immune escape. [PDF]

Front Immunol
Ni G, Qian N, Jiang Y, Tian R, Huang T, Li S.   +5 more
europepmc   +1 more source

Enhancing Anti-CTLA-4 Antibody Delivery to the Brain Using Focused Ultrasound and Microbubbles. [PDF]

Immunotargets Ther
Afonso Pereira M, Drevenakova V, Liu QE, Grewal S, Morse SV.   +4 more
europepmc   +1 more source

Cardiotoxicity of Antitumor Agents: Therapeutic Challenges in Heart Failure with Reduced and Preserved Ejection Fraction. [PDF]

Int J Mol Sci
Tana M, Piccinini R, Pinterpe G, Porreca E, Berardi R, Tana C.   +5 more
europepmc   +1 more source

The Efficacy and Safety of Beta-blockers and Immune Checkpoint Inhibitors in Patients with Cancer: A Systematic Review and Meta-analysis. [PDF]

Target Oncol
Tokunaga K, Fujiwara Y, Omori R, Sato T, Ahluwalia MS, Mukherjee S.   +5 more
europepmc   +1 more source

Rewiring tumor-associated macrophages in hepatocellular carcinoma. [PDF]

Front Immunol
Han X, Jin R.
europepmc   +1 more source

Special issue: advances in immunology and its applications. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Han M, Wang H.
europepmc   +1 more source