Results 71 to 80 of about 161,983 (298)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Immune Checkpoint Inhibitors for Lung Cancer Treatment: A Review

Journal of Clinical Medicine, 2020
The treatment of lung cancer has changed drastically in recent years owing to the advent of immune checkpoint inhibitors (ICIs). A 1992 study reported that programmed cell death-1 (PD-1), an immune checkpoint molecule, is upregulated during the induction
Keisuke Onoi, Y. Chihara, J. Uchino, Takayuki Shimamoto, Yoshie Morimoto, M. Iwasaku, Y. Kaneko, Tadaaki Yamada, K. Takayama   +8 more
semanticscholar   +1 more source

Study and analysis of antitumor resistance mechanism of PD1/PD‐L1 immune checkpoint blocker [PDF]

Cancer Medicine, 2020
AbstractImmunocheckpoint proteins of tumor infiltrating lymphocytes play an important role in tumor prognosis in the course of tumor clinicopathology. PD‐1 (Programmed cell death protein 1) is an important immunosuppressive molecule. By binding to PD‐L1 (programmed cell death‐ligand 1), it blocks TCR and its costimulus signal transduction, inhibits the
Zhengyi Wang, Xiaoying Wu
openaire   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction

Cancer Medicine, 2019
Immune checkpoint blockade (ICB) represents a promising approach in cancer therapy. Owing to the peculiar biologic mechanisms of anticancer activity, checkpoint blockers are accompanied with distinctive response patterns and toxicity profiles.
Hong Wei, Hanyu Jiang, Bin Song
doaj   +1 more source

Identification of a Ferroptosis-Related Long Noncoding RNA Prognostic Signature and Its Predictive Ability to Immunotherapy in Hepatocellular Carcinoma

Frontiers in Genetics, 2021
Background: Immune checkpoint blockers (ICBs) are increasingly being used to treat patients with advanced hepatocellular carcinoma (HCC), but only a third of these patients are sensitive to ICBs.
Liang Wang, Liang Wang, Xiangwei Ge, Zifeng Zhang, Yating Ye, Ziyi Zhou, Manhong Li, Hongxiang Yan, Lei Wu, Qian Bai, Jipeng Li, Jun Zhu, Jun Zhu, Yusheng Wang   +13 more
doaj   +1 more source

A CASE OF ACUTE CARDIOMYOPATHY DUE TO IMMUNE CHECKPOINT BLOCKER PEMBROLIZUMAB

Journal of the American College of Cardiology, 2020
The use of immune checkpoint inhibitors (ICI) in management of many cancers has increased recently, given their exceptional efficacy in ensuring remission. However, their inflammatory side effects have been associated with cardio-toxicity A 71-year-old man with metastatic renal cell carcinoma (
Raghavendra Makam, Youssef Rahban, David Gerson, Glenn Stokken   +3 more
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

TREX1 dictates the immune fate of irradiated cancer cells

OncoImmunology, 2017
The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA.
Claire Vanpouille-Box, Silvia C. Formenti, Sandra Demaria   +2 more
doaj   +1 more source