Results 51 to 60 of about 10,758 (225)
Experimental and Molecular Medicine, 2018 Cancer immunotherapy: Boosting anti-tumor immunity New immunotherapies for cancer known as immune checkpoint blockers (ICBs) may help treat many tumor types.
Young-Jun Park +2 more
doaj +1 more source
Brain Sciences, 2022 Low-grade glioma (LGG) is a highly aggressive disease in the skull. On the other hand, anoikis, a specific form of cell death induced by the loss of cell contact with the extracellular matrix, plays a key role in cancer metastasis. In this study, anoikis-
Songyun Zhao +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A CASE OF ACUTE CARDIOMYOPATHY DUE TO IMMUNE CHECKPOINT BLOCKER PEMBROLIZUMAB
Journal of the American College of Cardiology, 2020 The use of immune checkpoint inhibitors (ICI) in management of many cancers has increased recently, given their exceptional efficacy in ensuring remission. However, their inflammatory side effects have been associated with cardio-toxicity A 71-year-old man with metastatic renal cell carcinoma (
Raghavendra Makam +3 more
openaire +1 more source
Rationale for combination of radiation therapy and immune checkpoint blockers to improve cancer treatment [PDF]
Acta Oncologica, 2019 Radiation therapy for cancer is considered to be immunosuppressive. However, the cellular response after radiation therapy may stimulate or suppress an immune response. The effect may vary with the tumor type and occasionally tumor regressions have been observed outside the irradiated volume, both in animal studies and in the clinic. A renewed interest
Olav, Dahl +2 more
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Cancer Medicine, 2019 Immune checkpoint blockade (ICB) represents a promising approach in cancer therapy. Owing to the peculiar biologic mechanisms of anticancer activity, checkpoint blockers are accompanied with distinctive response patterns and toxicity profiles.
Hong Wei, Hanyu Jiang, Bin Song
doaj +1 more source
Frontiers in Genetics, 2021 Background: Immune checkpoint blockers (ICBs) are increasingly being used to treat patients with advanced hepatocellular carcinoma (HCC), but only a third of these patients are sensitive to ICBs.
Liang Wang +13 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Antidrug Antibodies Against Immune Checkpoint Blockers: Impairment of Drug Efficacy or Indication of Immune Activation? [PDF]
Clinical Cancer Research, 2020 Abstract The generation of antibodies following exposure to therapeutic drugs has been widely studied, however in oncology, data in relation to their clinical relevance are limited. Antidrug antibodies (ADAs) can cause a decrease in the amount of drug available, resulting in some cases in decreased antitumor activity and a consequent ...
Diego Enrico +4 more
openaire +2 more sources