Results 51 to 60 of about 15,424 (278)

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment [PDF]

, 2016
Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methylating agent ...
Catalano, Myriam, Chece, Giuseppina, D'Alessandro, Giuseppina, Di Angelantonio, Silvia, Esposito, Vincenzo, Esposito, Vincenzo, Grimaldi, Alfonso, Limatola, Cristina, Mainiero, Fabrizio, Porzia, Alessandra, Ragozzino, Davide, Salvati, Maurizio, Santoro, Antonio, Wulff, Heike   +13 more
core   +3 more sources

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy [PDF]

, 2018
Checkpoint blockade immunotherapies can be extraordinarily effective, but might benefit only the minority of patients whose tumors are pre-infiltrated by T cells.
Cortez-Retamozo, Virna, Engblom, Camilla, Freeman, Gordon J., Garris, Christopher, Huynh, Tiffany G., Hynes, Richard O., Iwamoto, Yoshiko, Kroemer, Guido, Lin, Yi-Jang, Mino-Kenudson, Mari, Newton, Andita, Pfirschke, Christina, Pittet, Mikael J., Poirier-Colame, Vichnou, Pucci, Ferdinando, Redouane, Younes, Rickelt, Steffen, Weissleder, Ralph, Wojtkiewicz, Gregory, Yamazaki, Takahiro, Zitvogel, Laurence   +20 more
core   +1 more source

Antidrug Antibodies Against Immune Checkpoint Blockers: Impairment of Drug Efficacy or Indication of Immune Activation? [PDF]

Clinical Cancer Research, 2020
Abstract The generation of antibodies following exposure to therapeutic drugs has been widely studied, however in oncology, data in relation to their clinical relevance are limited. Antidrug antibodies (ADAs) can cause a decrease in the amount of drug available, resulting in some cases in decreased antitumor activity and a consequent ...
Diego Enrico, Angelo Paci, Nathalie Chaput, Eleni Karamouza, Benjamin Besse   +4 more
openaire   +2 more sources

The impact of peroxisome proliferator‐activated receptor‐γ activating angiotensin receptor blocker on outcomes of patients receiving immunotherapy

Cancer Medicine, 2023
Background Certain angiotensin receptor blockers (ARBs) have peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) activation property, which has been associated with improved programmed cell death ligand 1 blockade and cytotoxic T lymphocyte‐mediated ...
Cho‐Han Chiang, Yu‐Cheng Chang, Shih‐Syuan Wang, Yuan‐Jen Chen, Xin Ya See, Chun‐Yu Peng, Yuan Ping Hsia, Cho‐Hsien Chiang, Cho‐Hung Chiang, Cheng‐Ming Peng   +9 more
doaj   +1 more source

Nivolumab and immune-mediated colitis [PDF]

, 2019
Nivolumab is associated with a number of immune-regulated adverse events, including immune-mediated colitis and may present following the discontinuation of treatment.
Brennan, Paul, Carey, Frank, Groome, Maximillian, Walker, Heather, Walsh, Shaun   +4 more
core   +2 more sources

The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors

Cell Communication and Signaling, 2022
Innate and adaptive immune cells patrol and survey throughout the human body and sometimes reside in the tumor microenvironment (TME) with a variety of cell types and nutrients that may differ from those in which they developed.
Hamidreza Zalpoor, Fatemeh Aziziyan, Mahsa Liaghat, Maryam Bakhtiyari, Abdullatif Akbari, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani, Nima Rezaei   +7 more
doaj   +1 more source

Modern cancer therapy: cryoablation meets immune checkpoint blockade

Frontiers in Oncology
Cryoablation, as a minimally invasive technology for the treatment of tumors, destroys target tumors with lethal low temperatures. It simultaneously releases a large number of tumor-specific antigens, pro-inflammatory cytokines, and nucleoproteins, known
Qi Liu, Qi Liu, Chunyang Zhang, Chunyang Zhang, Xuxin Chen, Xuxin Chen, Zhihai Han, Zhihai Han, Zhihai Han   +8 more
doaj   +1 more source

HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to neoadjuvant chemotherapy [PDF]

, 2018
Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Borralho, Paula, Braga, Sofia, Cabral, M. Guadalupe, Jacinto, António, Saraiva, Diana P.   +4 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Novel immune checkpoint blocker approved for the treatment of advanced melanoma

OncoImmunology, 2014
A few days ago, on September 4th, 2014, the US Food and Drug Administration (FDA) granted accelerated approval to pembrolizumab, a monoclonal antibody formerly known as lambrolizumab that specifica...
Lorenzo Galluzzi, Guido Kroemer, Alexander Eggermont   +2 more
openaire   +2 more sources