Results 241 to 250 of about 204,987 (288)

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

A case of diverse psychiatric and functional impairments following immune checkpoint inhibitor therapy. [PDF]

PCN Rep
Ikegami T, Sadahiro R, Yamaguchi J, Nishikawa E, Wada S, Terada T, Nakahara R, Matsuoka H.   +7 more
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Immune Checkpoint Inhibitor Outcomes in NSCLC Across Populations and Practice Settings. [PDF]

JTO Clin Res Rep
Lee M, Liu J, Teigen KJ, Sabloak K, Howell M, Gonzalez M, Ghabach B, Gerber DE, Narra K, von Itzstein MS.   +9 more
europepmc   +1 more source

Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials [PDF]

, 2017
et al,, Mutch, David G
core   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Isolated immune-mediated enteritis in patients treated with immune checkpoint inhibitor therapy. [PDF]

Ann Gastroenterol
Wali S, Patel RS, Santos MJMN, Chatterjee A, Fan SC, Ngo S, Gupta T, Baki KA, Heinzerling L, Schneider BJ, Bollin K, Philpott J, Thomas A, Wang Y.   +13 more
europepmc   +1 more source

The clinical characteristics, mechanism and management of immune checkpoint inhibitor-related arthritis. [PDF]

Front Immunol
Gao J, Miao J, Chen Z, Zhu P.
europepmc   +1 more source

Incidence of Immune Checkpoint Inhibitor-Associated Renal Tubular Acidosis. [PDF]

Kidney Int Rep
Shah CV, Kim EM, Mathavan A, Mathavan A, Shah N, Ilyas M, Nguyen J, Weiner ID.   +7 more
europepmc   +1 more source